Gene

bmpr1ba

ID
ZDB-GENE-991208-8
Name
bone morphogenetic protein receptor, type IBa
Symbol
bmpr1ba Nomenclature History
Previous Names
  • BMPR-IB (1)
  • bmpr1b
  • BR1b
  • alk6
  • alk6tr
  • zALK-6
  • zgc:92220
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to have SMAD binding activity and transforming growth factor beta receptor activity, type I. Involved in BMP signaling pathway and determination of dorsal identity. Predicted to localize to plasma membrane and receptor complex. Is expressed in several structures, including anterior neural rod; margin; nervous system; optic primordium; and ovarian follicle. Human ortholog(s) of this gene implicated in brachydactyly type A1D; brachydactyly type A2; and osteochondrodysplasia. Orthologous to human BMPR1B (bone morphogenetic protein receptor type 1B).
Genome Resources
Note
None
Expression
All Expression Data
16 figures from 10 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Maurya et al., 2011
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With bmpr1ba Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
brachydactyly type A1D Alliance Brachydactyly, type A1, D 616849
brachydactyly type A2 Alliance Brachydactyly, type A2 112600
Acromesomelic dysplasia, Demirhan type 609441
Associated With bmpr1ba Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000472 Activin types I and II receptor domain
Domain IPR000719 Protein kinase domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR003605 GS domain
Family IPR000333 Ser/Thr protein kinase, TGFB receptor
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Domain Details Per Protein
Protein Length Activin types I and II receptor domain GS domain Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site Serine-threonine/tyrosine-protein kinase, catalytic domain Ser/Thr protein kinase, TGFB receptor
UniProtKB:Q9W629 530
UniProtKB:F1RC58 504
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations