Gene
nog1
- ID
- ZDB-GENE-991206-8
- Name
- noggin 1
- Symbol
- nog1 Nomenclature History
- Previous Names
-
- zNog1
- fc23h06
- wu:fc23h06 (1)
- Type
- protein_coding_gene
- Location
- Chr: 3 Mapping Details/Browsers
- Description
- Involved in dorsal/ventral pattern formation; negative regulation of BMP signaling pathway; and negative regulation of endodermal cell fate specification. Localizes to Golgi apparatus and synapse. Human ortholog(s) of this gene implicated in Huntington's disease; cleft lip; dysostosis (multiple); hyperopia; and proximal symphalangism. Is expressed in several structures, including central nervous system; mesoderm; neural tube; optic vesicle; and presumptive shield. Orthologous to human NOG (noggin).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 21 figures from 18 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 2 figures from Dal-Pra et al., 2006
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| brachydactyly type B2 | Alliance | Brachydactyly, type B2 | 611377 |
| multiple synostoses syndrome 1 | Alliance | Multiple synostoses syndrome 1 | 186500 |
| proximal symphalangism 1 | Alliance | Symphalangism, proximal, 1A | 185800 |
| tarsal-carpal coalition syndrome | Alliance | Tarsal-carpal coalition syndrome | 186570 |
| Stapes ankylosis with broad thumbs and toes | 184460 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Cystine-knot cytokine | Noggin |
|---|---|---|---|
|
UniProtKB:Q6NV45
|
216 | ||
|
UniProtKB:Q9W741
|
216 |
Interactions and Pathways
No data available
Plasmids
No data available