Gene

nog1

ID
ZDB-GENE-991206-8
Name
noggin 1
Symbol
nog1 Nomenclature History
Previous Names
  • zNog1
  • fc23h06
  • wu:fc23h06 (1)
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Involved in dorsal/ventral pattern formation; negative regulation of BMP signaling pathway; and negative regulation of endodermal cell fate specification. Localizes to Golgi apparatus and synapse. Is expressed in several structures, including central nervous system; mesoderm; neural tube; optic vesicle; and presumptive shield. Human ortholog(s) of this gene implicated in Huntington's disease; cleft lip; dysostosis (multiple); hyperopia; and proximal symphalangism. Orthologous to human NOG (noggin).
Genome Resources
Note
None
Expression
All Expression Data
17 figures from 14 publications
Cross-Species Comparison
High Throughput Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Dal-Pra et al., 2006
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With nog1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
brachydactyly type B2 Alliance Brachydactyly, type B2 611377
multiple synostoses syndrome Alliance Multiple synostoses syndrome 1 186500
proximal symphalangism Alliance Symphalangism, proximal, 1A 185800
tarsal-carpal coalition syndrome Alliance Tarsal-carpal coalition syndrome 186570
Stapes ankylosis with broad thumbs and toes 184460
Associated With nog1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Family IPR008717 Noggin
Homologous_superfamily IPR029034 Cystine-knot cytokine
Domain Details Per Protein
Protein Length Cystine-knot cytokine Noggin
UniProtKB:Q9W741 216
UniProtKB:Q6NV45 216
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations