ZFIN ID: ZDB-GENE-991019-9
Gene Name: tropomodulin 4 (muscle)
Gene Symbol: tmod4    Nomenclature History

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Previous Names: Sk-Tmod (1), sktmod (1), fa12b03, skeletal tropomodulin (1), wu:fa12b03

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 16 Mapping Details/Browsers
Description: Predicted to have tropomyosin binding activity. Involved in skeletal myofibril assembly. Predicted to localize to the striated muscle thin filament. Is expressed in head muscle and myotome. Orthologous to human TMOD4 (tropomodulin 4).
Genome Resources: Alliance (1),  Gene:30441 (1),  Ensembl(GRCz11):ENSDARG00000020890 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu3476 Point Mutation Unknown Missense ENU
hu3530 Point Mutation Unknown Premature Stop ENU
pc20 Point Mutation Exon 5 Premature Stop
sa18609 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa22870 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-tmod4 N/A 1
    DISEASE ASSOCIATED WITH tmod4 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH tmod4 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process skeletal myofibril assembly (more)
    Cellular Component cytoskeleton (more)
    Molecular Function actin filament binding (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR004934 Tropomodulin
    Family IPR030129 Tropomodulin-4
    Homologous_superfamily IPR032675 Leucine-rich repeat domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tmod4-201 (1)    Ensembl 1717
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-tmod4 polyclonal IgG Rabbit WB Proteintech
    2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tmod4 No data available
    MARKER RELATIONSHIPS
    tmod4 Contained in: [BAC] CH211-203D17 (1)
    tmod4 Encodes: [EST] fa12b03
    [cDNA] MGC:77859 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131196 (1) 1442 bp
    Genomic GenBank:CT954330 (1) 69840 bp
    Select Tool
    Polypeptide UniProtKB:Q9PUQ6 (1) 343 aa
    Sequence Information (all 15)
    ORTHOLOGY for tmod4 ( Chr: 16 )
    CITATIONS (25)