ZFIN ID: ZDB-GENE-990715-2
Gene Name: sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D
Gene Symbol: sema3d    Nomenclature History

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Previous Names: sema2, sema3D (1), semaZ2 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 18 Mapping Details/Browsers
Description: Predicted to have chemorepellent activity; neuropilin binding activity; and semaphorin receptor binding activity. Involved in several processes, including animal organ development; fin regeneration; and nervous system development. Predicted to localize to the extracellular space and integral component of plasma membrane. Is expressed in several structures, including central nervous system; hindbrain neural keel; neural crest; pharyngeal arch; and posterior lateral line system. Orthologous to human SEMA3D (semaphorin 3D).
Genome Resources: Alliance (1),  Gene:30250 (1),  Ensembl(GRCz11):ENSDARG00000017369 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la020551Tg Transgenic Insertion Unknown Unknown DNA
mu268 Small Deletion Unknown Unknown CRISPR
sa1661 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15069 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa19196 Point Mutation Unknown Premature Stop ENU
    sa28980 Point Mutation Unknown Splice Site ENU
    sa30702 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa36576 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43051 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44882 Point Mutation Unknown Unknown ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-sema3d 1
    CRISPR2-sema3d
    1
    CRISPR3-sema3d
    1
    MO1-sema3d N/A 2
    MO2-sema3d N/A 10
    MO3-sema3d N/A 6
    MO4-sema3d N/A 1
    MO5-sema3d N/A 4
    MO6-sema3d N/A 1
    DISEASE ASSOCIATED WITH sema3d HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH sema3d VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process enteric nervous system development (more)
    Cellular Component extracellular region (more)
    Molecular Function neuropilin binding (more)
    GO Terms (all 33)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR001627 Sema domain
    Domain IPR016201 PSI domain
    Domain IPR042582 Semaphorin-3D, Sema domain
    Family IPR027231 Semaphorin
    Homologous_superfamily IPR013783 Immunoglobulin-like fold
    Homologous_superfamily IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
    Homologous_superfamily IPR036352 Sema domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA sema3d-201 (1)    Ensembl 2814
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-sema3d polyclonal Rabbit IHC Sigma-Aldrich
    3
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM sema3d
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(hsp70l:sema3d-6xMYC) hsp70l sema3d Danio rerio 1 7
    Tg(hsp70l:sema3d-GFP) hsp70l GFPsema3d Danio rerio 1 2
    MARKER RELATIONSHIPS
    sema3d Contained in: [BAC] CH73-91H12 (1)
    [Fosmid] CH1073-181J18 (1), CH1073-455M18 (1)
    sema3d Encodes: [EST] eu640 (1), fb95a06 (1) (order this)
    [cDNA] MGC:193649 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131048 (1) 2879 nt
    Genomic GenBank:CU855784 (1) 56005 nt
    Select Tool
    Polypeptide UniProtKB:A0A0B5JFC0 (1) 764 aa
    Sequence Information (all 24)
    ORTHOLOGY for sema3d ( Chr: 18 )
    CITATIONS (65)