Gene
skib
- ID
- ZDB-GENE-990715-10
- Name
- v-ski avian sarcoma viral oncogene homolog b
- Symbol
- skib Nomenclature History
- Previous Names
-
- skiB
- fc17g02
- wu:fc17g02 (1)
- wu:fk79g04
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to have SMAD binding activity and transcription corepressor activity. Involved in cartilage development; dorsal/ventral pattern formation; and heart looping. Localizes to nucleus. Used to study craniosynostosis. Is expressed in central nervous system. Orthologous to human SKI (SKI proto-oncogene).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| craniosynostosis | Alliance | Shprintzen-Goldberg syndrome | 182212 |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| craniosynostosis | WT + MO1-skib | standard conditions | Doyle et al., 2012 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR003380 | SKI/SNO/DAC domain |
| Domain | IPR014890 | c-SKI SMAD4-binding domain |
| Domain | IPR047315 | Ski oncogene-like, Dachshund-homology domain |
| Family | IPR023216 | Transcription regulator SKI/SnoN |
| Homologous_superfamily | IPR009061 | Putative DNA-binding domain superfamily |
| Homologous_superfamily | IPR010919 | SAND-like domain superfamily |
| Homologous_superfamily | IPR037000 | Ski-like, DNA-binding domain superfamily |
Domain Details Per Protein
| Protein | Length | c-SKI SMAD4-binding domain | Putative DNA-binding domain superfamily | SAND-like domain superfamily | Ski-like, DNA-binding domain superfamily | Ski oncogene-like, Dachshund-homology domain | SKI/SNO/DAC domain | Transcription regulator SKI/SnoN |
|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q9YI02
|
695 |
Interactions and Pathways
No data available
Plasmids
No data available