ZFIN ID: ZDB-GENE-990714-22
Gene Name: acetyl-CoA acetyltransferase 2
Gene Symbol: acat2    Nomenclature History

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Previous Names: etID39354.20 (1), fb10a06, fb53f08, wu:fb10a06 (1), wu:fb53f08 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have acetyl-CoA C-acetyltransferase activity. Predicted to be involved in fatty acid beta-oxidation. Predicted to localize to mitochondrion. Is expressed in central nervous system; hindbrain; liver; neurons; and yolk syncytial layer. Human ortholog(s) of this gene implicated in coronary artery disease. Orthologous to human ACAT2 (acetyl-CoA acetyltransferase 2).
Genome Resources: Alliance (1),  Gene:30643 (1),  Ensembl(GRCz11):ENSDARG00000007127 (2)
GENE EXPRESSION
All Expression Data: 6 figures from 3 publications
Directly Submitted Expression Data: 4 figures (6 images) from Thisse et al., 2004 [MGC:56153]
  1 figure (1 image) from Thisse et al., 2005 [eu94]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la028243Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32299 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH acat2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    ?ACAT2 deficiency 614055
    DISEASE ASSOCIATED WITH acat2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process fatty acid beta-oxidation (more)
    Cellular Component mitochondrion (more)
    Molecular Function catalytic activity (more)
    GO Terms (all 8)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA acat2-201 (1)    Ensembl 1938
    acat2-202 (1)    Ensembl 656
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM acat2 No data available
    MARKER RELATIONSHIPS
    acat2 Contained in: [BAC] CH211-195E3 (1)
    acat2 Encodes: [EST] eu94 (1), fb10a06 (1), fb53f08 (1)
    [cDNA] MGC:56153 (1), MGC:192398 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131370 (1) 1954 nt
    Genomic GenBank:AL929182 (1) 225515 nt Blast at MegaBLAST
    Polypeptide UniProtKB:Q5SPA3 (1) 395 aa
    Sequence Information (all 25)
    ORTHOLOGY for acat2 ( Chr: 20 )
    CITATIONS (37)