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ZIRC
ZFIN ID: ZDB-GENE-990714-22
Gene Name: acetyl-CoA acetyltransferase 2
Gene Symbol: acat2    Nomenclature History

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Previous Names: etID39354.20 (1), fb10a06, fb53f08, wu:fb10a06 (1), wu:fb53f08 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have acetyl-CoA C-acetyltransferase activity. Predicted to be involved in fatty acid beta-oxidation. Predicted to localize to the mitochondrion. Human ortholog(s) of this gene implicated in coronary artery disease. Is expressed in central nervous system; hindbrain; liver; neurons; and yolk syncytial layer. Orthologous to human ACAT2 (acetyl-CoA acetyltransferase 2).
Genome Resources: Alliance (1),  Gene:30643 (1),  Ensembl(GRCz11):ENSDARG00000007127 (2)
GENE EXPRESSION
All Expression Data: 6 figures from 3 publications
Directly Submitted Expression Data: 4 figures (6 images) from Thisse et al., 2004 [MGC:56153]
  1 figure (1 image) from Thisse et al., 2005 [eu94]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Hatching:Pec-fin (60.0h-72.0h)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la028243Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32299 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH acat2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    ?ACAT2 deficiency 614055
    DISEASE ASSOCIATED WITH acat2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process fatty acid beta-oxidation (more)
    Cellular Component mitochondrion (more)
    Molecular Function catalytic activity (more)
    GO Terms (all 8)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA acat2-201 (1)    Ensembl 1938
    acat2-202 (1)    Ensembl 656
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM acat2 No data available
    MARKER RELATIONSHIPS
    acat2 Contained in: [BAC] CH211-195E3 (1) (order this)
    acat2 Encodes: [EST] eu94 (1), fb10a06 (1), fb53f08 (1)
    [cDNA] MGC:56153 (1) (order this), MGC:192398 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131370 (1) 1954 bp
    Genomic GenBank:AL929182 (1) 225515 bp Blast at MegaBLAST
    Polypeptide UniProtKB:Q5SPA3 (1) 395 aa
    Sequence Clusters UniGene:813 (1)
    Sequence Information (all 26)
    ORTHOLOGY for acat2 ( Chr: 20 )
    CITATIONS (36)