header logo image header logo text
Downloads Login
Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-990708-6
Gene Name: forkhead box O3b
Gene Symbol: foxo3b    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: foxo5, fkhr (1), wu:fj65a12 (1), zFkhr (1)

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific; sequence-specific DNA binding activity; and transcription factor binding activity. Involved in several processes, including negative regulation of canonical Wnt signaling pathway; negative regulation of defense response to virus; and primitive hemopoiesis. Predicted to localize to the cytoplasm and nucleus. Is expressed in several structures, including immune system; liver; nervous system; pericardial region; and posterior lateral mesoderm. Orthologous to human FOXO3 (forkhead box O3).
Genome Resources: Alliance (1),  Gene:30296 (1),  Ensembl(GRCz11):ENSDARG00000042904 (2)
GENE EXPRESSION
All Expression Data: 10 figures from 10 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2005 [eu663]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ihb404 Insertion Exon 2 Frameshift, Premature Stop CRISPR
sa37075 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-foxo3b 2
    MO1-foxo3b N/A 3
    MO2-foxo3b N/A 3
    DISEASE ASSOCIATED WITH foxo3b HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH foxo3b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process negative regulation of canonical Wnt signaling pathway (more)
    Cellular Component nucleus (more)
    Molecular Function protein binding (more)
    GO Terms (all 19)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA foxo3b-201 (1)    Ensembl 4540
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM foxo3b No data available
    MARKER RELATIONSHIPS
    foxo3b Contained in: [BAC] CH211-278N15 (1) (order this), DKEYP-34A4 (1)
    foxo3b Encodes: [EST] eu663 (1), fj65a12 (1)
    [cDNA] MGC:193582 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131085 (1) 4547 bp
    Genomic GenBank:BX927123 (1) 121145 bp
    Select Tool
    Polypeptide UniProtKB:B3DGQ4 (1) 651 aa
    Sequence Clusters UniGene:78161 (1)
    Sequence Information (all 22)
    ORTHOLOGY for foxo3b ( Chr: 20 )
    CITATIONS (45)