Gene

smad2

ID
ZDB-GENE-990603-7
Name
SMAD family member 2
Symbol
smad2 Nomenclature History
Previous Names
  • madh2
  • fj43c06
  • SMA- and MAD-related protein 2
  • wu:fj43c06
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Exhibits DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; neural plate anterior/posterior regionalization; and positive regulation of oocyte development. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in Lynch syndrome; cervical cancer; and ovarian cancer. Is expressed in brain; head; immature eye; and tail bud. Orthologous to human SMAD2 (SMAD family member 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
12 figures from 9 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
8 figures from 8 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With smad2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Congenital heart defects, multiple types, 8, with or without heterotaxy 619657
Loeys-Dietz syndrome 6 619656
Associated With smad2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001132 SMAD domain, Dwarfin-type
Domain IPR003619 MAD homology 1, Dwarfin-type
Domain IPR013019 MAD homology, MH1
Family IPR013790 Dwarfin
Homologous_superfamily IPR008984 SMAD/FHA domain superfamily
Homologous_superfamily IPR017855 SMAD-like domain superfamily
Homologous_superfamily IPR036578 SMAD MH1 domain superfamily
Domain Details Per Protein
Protein Length Dwarfin MAD homology 1, Dwarfin-type MAD homology, MH1 SMAD domain, Dwarfin-type SMAD/FHA domain superfamily SMAD-like domain superfamily SMAD MH1 domain superfamily
UniProtKB:Q9I9P9 468
UniProtKB:E9QE59 74
UniProtKB:Q7ZU35 468
UniProtKB:F1Q5P5 469
UniProtKB:E9QJE3 160
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab-smad2 polyclonal Rabbit
  • IHC
  • WB
Cell Signaling Technology, Inc.
13
Ab2-smad2 monoclonal IgG Rabbit
  • IHC
Millipore
6
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations