ZFIN Gene: cse1l

ZFIN ID: ZDB-GENE-990603-1

ZFIN ID: ZDB-GENE-990603-1

Gene Name:

CSE1 chromosome segregation 1-like (yeast)

Gene Symbol:

cse1l Nomenclature History

Previous Names:

bao (1), baobab (1), cas, cellular apoptosis susceptibility gene

Gene Type:

protein_coding_gene

Location:

Chr: 11 Mapping Details/Browsers

Description:

Predicted to have nuclear export signal receptor activity. Involved in body fluid secretion. Predicted to localize to cytosol and nuclear envelope. Is expressed in brain; digestive system; endoderm; and retina. Orthologous to human CSE1L (chromosome segregation 1 like).

Genome Resources:

Alliance (1), Gene:30707 (1), Ensembl(GRCz11):ENSDARG00000006963 (2)

GENE EXPRESSION
All Expression Data:	3 figures from 3 publications
Directly Submitted Expression Data:	1 figure (1 image) from Thisse et al., 2004 [MGC:55932]
Wild-type Stages, Structures:	Zygote:1-cell (0.0h-0.75h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
	brain endoderm enterocyte apical part of cell enterocyte basal plasma membrane enterocyte lateral plasma membrane exocrine pancreas gut liver retina unspecified whole organism
High Throughput Expression:	GEO (1) , Expression Atlas (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
s866	Point Mutation	Unknown	Splice Site
sa7357	Point Mutation	Unknown	Missense	ENU
sa35010	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa35011	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
MO1-cse1l	N/A	1

PHENOTYPE

Data:	5 figures from Bagnat et al., 2010
Observed in:	digestive tract development enterocyte microvillus enterocyte exocrine pancreas exocrine pancreas development gut gut epithelium intestinal villus intracellularly ATP-gated chloride channel activity liver liver development

DISEASE ASSOCIATED WITH cse1l HUMAN ORTHOLOG No data available

DISEASE ASSOCIATED WITH cse1l VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	body fluid secretion (more)
Cellular Component	apical plasma membrane (more)
Molecular Function	protein binding (more)

GO Terms (all 17)

PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	cse1l-201 (1)	3581	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: UCSC, NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

ANTIBODIES

Name	Type	Isotype	Host Organism	Assay	Source	Publications
Ab1-cse1l	polyclonal	IgG	Rabbit	IHC, WB	Bethyl Laboratories, Inc.	2

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM cse1l No data available

MARKER RELATIONSHIPS

cse1l Contained in:	[BAC] DKEY-33G10 (1) (order this)
cse1l Encodes:	[cDNA] MGC:55932 (1), MGC:76918 (1)

SEQUENCE INFORMATION

Type	Accession #	Length (nt/aa)	Analysis
RNA	RefSeq:NM_201450 (1)	3517 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CR559931 (1)	210732 nt	Blast at MegaBLAST
Polypeptide	UniProtKB:Q7SZC2 (1)	971 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast

Sequence Information (all 13)

ORTHOLOGY for cse1l ( Chr: 11 )

CITATIONS (29)

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