ZFIN ID: ZDB-GENE-990415-95
Gene Name: heat shock protein 90, alpha (cytosolic), class B member 1
Gene Symbol: hsp90ab1    Nomenclature History

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Previous Names: hsp90b (2), hsp90beta, wu:fa29f01, wu:fa91e11 (1), wu:fd59e11, wu:gcd22h07

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Predicted to have several functions, including ATP binding activity; protein dimerization activity; and unfolded protein binding activity. Involved in blood vessel development and leukocyte migration. Predicted to localize to several cellular components, including the aryl hydrocarbon receptor complex; cytosol; and extracellular region. Human ortholog(s) of this gene implicated in multiple sclerosis. Is expressed in eye and head. Orthologous to human HSP90AB1 (heat shock protein 90 alpha family class B member 1).
Genome Resources: Alliance (1),  Gene:30573 (1), 
GENE EXPRESSION
All Expression Data: 8 figures from 8 publications
Directly Submitted Expression Data: 1 figure (1 image) from Thisse et al., 2004 [MGC:77433]
  1 figure (1 image) from Rauch et al., 2003 [gcd22h07]
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
ihb299 Small Deletion Exon 3 Unknown CRISPR
ihb300 Small Deletion Exon 3 Unknown CRISPR
sa10 Point Mutation Unknown Splice Site ENU
sa12875 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15412 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-hsp90ab1 1
    MO1-hsp90ab1 N/A 2
    MO2-hsp90ab1 N/A 1
    MO3-hsp90ab1 N/A 2
    MO4-hsp90ab1 N/A 1
    MO5-hsp90ab1 N/A 1
    DISEASE ASSOCIATED WITH hsp90ab1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH hsp90ab1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process blood vessel development (more)
    Cellular Component aryl hydrocarbon receptor complex (more)
    Molecular Function protein binding (more)
    GO Terms (all 26)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Conserved_site IPR019805 Heat shock protein Hsp90, conserved site
    Domain IPR003594 Histidine kinase/HSP90-like ATPase
    Domain IPR020575 Heat shock protein Hsp90, N-terminal
    Family IPR001404 Heat shock protein Hsp90 family
    Homologous_superfamily IPR020568 Ribosomal protein S5 domain 2-type fold
    Homologous_superfamily IPR036890 Histidine kinase/HSP90-like ATPase superfamily
    Homologous_superfamily IPR037196 HSP90, C-terminal domain
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA hsp90ab1-201 (1)    Ensembl 3386
    ncRNA hsp90ab1-002 (1)    Ensembl 641
    hsp90ab1-003 (1)    Ensembl 511
    Browsers: NCBI
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM hsp90ab1 No data available
    MARKER RELATIONSHIPS
    hsp90ab1 Contained in: [BAC] CH73-132H10 (1)
    hsp90ab1 Encodes: [EST] fa29f01, fa91e11 (1), fd59e11, gcd22h07 (1) (order this)
    [cDNA] MGC:77433 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131310 (1) 2642 nt
    Genomic GenBank:CU075928 (1) 42472 nt
    Select Tool
    Polypeptide UniProtKB:O57521 (1) 725 aa
    Sequence Information (all 24)
    ORTHOLOGY for hsp90ab1 ( Chr: 20 )
    CITATIONS (65)