ZFIN ID: ZDB-GENE-990415-92
Gene Name: heat shock protein 8
Gene Symbol: hspa8    Nomenclature History

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Previous Names: heat shock cognate 71-kd protein, hsc70, wu:fb01g06 (1), wu:fi48b06 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Predicted to have several functions, including ATP binding activity; misfolded protein binding activity; and protein folding chaperone. Involved in several processes, including fin regeneration; positive regulation of receptor-mediated endocytosis; and protein localization to early endosome. Predicted to localize to cytosol; nucleus; and plasma membrane. Is expressed in several structures, including head; immature eye; nervous system; otic vesicle; and presumptive neural plate. Human ortholog(s) of this gene implicated in Parkinson's disease and renal hypertension. Orthologous to human HSPA8 (heat shock protein family A (Hsp70) member 8).
Genome Resources: Alliance (1),  Gene:573376 (1),  Ensembl(GRCz11):ENSDARG00000068992 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hi138Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la011844Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la017505Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41685 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45412 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-hspa8 N/A 4
    MO2-hspa8 N/A 1
    DISEASE ASSOCIATED WITH hspa8 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH hspa8 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process positive regulation of receptor-mediated endocytosis (more)
    Cellular Component cytoplasm (more)
    Molecular Function ATP binding (more)
    GO Terms (all 20)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA hspa8-201 (1)    Ensembl 2453
    hspa8-202 (1)    Ensembl 675
    hspa8-203 (1)    Ensembl 678
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM hspa8
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(hspa8:mAGFP-Hsa.GMNN.110) hspa8 mAGFP Danio rerioHomo sapiens 4 2
    Tg(hspa8:MITO-YC2) hspa8 YC2 Danio rerio 1 2
    Tg(hspa8:mKOFP2-Hsa.CDT1.120) hspa8 mKOFP2 Danio rerioHomo sapiens 3 2
    Tg(hspa8:YC2) hspa8 YC2 Danio rerio 1 2
    MARKER RELATIONSHIPS
    hspa8 Contained in: [BAC] RP71-56I13 (1)
    hspa8 Encodes: [EST] fb93b09 (1) (order this), fi48b06 (1)
    [cDNA] MGC:55272 (1), MGC:76861 (1), MGC:77588 (1), MGC:173731 (1), MGC:192805 (1)
    hspa8 Has Artifact: [EST] fb01g06
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001110403 (1) 2403 nt
    Genomic GenBank:BX120005 (1) 129782 nt
    Select Tool
    Polypeptide UniProtKB:A0A2R8QEN9 (1) 658 aa
    Sequence Information (all 44)
    ORTHOLOGY for hspa8 ( Chr: 10 )
    CITATIONS (77)