ZFIN ID: ZDB-GENE-990415-82
Gene Name: GATA binding protein 3
Gene Symbol: gata3    Nomenclature History

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Previous Names: gta3 (1), cb550 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 4 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including embryonic organ morphogenesis; generation of neurons; and tissue regeneration. Predicted to localize to nucleus. Is expressed in several structures, including digestive system; ectoderm; nervous system; neural tube; and pleuroperitoneal region. Used to study hypoparathyroidism-retardation-dysmorphism syndrome. Human ortholog(s) of this gene implicated in hypoparathyroidism; hypoparathyroidism-deafness-renal disease syndrome; nephrosis; and sensorineural hearing loss. Orthologous to human GATA3 (GATA binding protein 3).
Genome Resources: Alliance (1),  Gene:30458 (1),  Ensembl(GRCz11):ENSDARG00000016526 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
b1075 Point Mutation Exon 4 Missense
sa0234 Indel Unknown Premature Stop ZINC_FINGER_NUCLEASE
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20285 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40301 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40302 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40303 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • stl600Tg Transgenic Insertion Unknown Unknown
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-gata3 1
    MO1-gata3 N/A 6
    MO2-gata3 N/A 2
    MO3-gata3 N/A 1
    MO4-gata3 N/A 2
    DISEASE ASSOCIATED WITH gata3 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    hypoparathyroidism-deafness-renal disease syndrome Alliance Hypoparathyroidism, sensorineural deafness, and renal dysplasia 146255
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process fibroblast growth factor receptor signaling pathway (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 30)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA gata3-201 (1)    Ensembl 2576
    ncRNA gata3-002 (1)    Ensembl 685
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gata3
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(gata3:AmCyan) gata3 AmCyan Danio rerio 1 2
    Tg(HSE-CMV:gata3,EGFP) CMVHSE EGFPgata3 Danio rerio 1 1
    Tg(hsp70l:gata3) hsp70l gata3 Danio rerio 1 2
    tgbac(gata3:gal4) gata3 GAL4 Danio rerio 1 2
    tgbac(gata3:loxp-dsred-loxp-gfp) gata3 DsRedGFPLOXP Danio rerio 1 2
    MARKER RELATIONSHIPS
    gata3 Contained in: [BAC] DKEY-268B12 (1) (order this)
    gata3 Encodes: [EST] cb550 (1) (order this)
    [cDNA] MGC:194063 (1), MGC:194082 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131211 (1) 2576 nt
    Genomic GenBank:BX901908 (1) 210697 nt Blast at MegaBLAST
    Polypeptide UniProtKB:B3DGG5 (1) 438 aa
    Sequence Information (all 29)
    ORTHOLOGY for gata3 ( Chr: 4 )
    CITATIONS (127)