Gene
ephb4b
- ID
- ZDB-GENE-990415-65
- Name
- eph receptor B4b
- Symbol
- ephb4b Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to have transmembrane receptor protein tyrosine kinase activity. Involved in Kupffer's vesicle development and somitogenesis. Predicted to localize to integral component of plasma membrane and receptor complex. Human ortholog(s) of this gene implicated in hereditary lymphedema. Is expressed in several structures, including anterior neural keel; central nervous system; forerunner cell group; neural tube; and tail bud. Orthologous to human EPHB4 (EPH receptor B4).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- cb417 (36 images)
Wild Type Expression Summary
- All Phenotype Data
- 3 figures from Zhang et al., 2016
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| central conducting lymphatic anomaly | Alliance | Lymphatic malformation 7 | 617300 |
| Capillary malformation-arteriovenous malformation 2 | 618196 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001090 | Ephrin receptor ligand binding domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR001660 | Sterile alpha motif domain |
| Domain | IPR003961 | Fibronectin type III |
| Domain | IPR020635 | Tyrosine-protein kinase, catalytic domain |
| Domain | IPR027936 | Ephrin receptor, transmembrane domain |
| Family | IPR016257 | Ephrin receptor type-A /type-B |
| Family | IPR050449 | Ephrin receptor tyrosine kinases |
| Homologous_superfamily | IPR008979 | Galactose-binding-like domain superfamily |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR013761 | Sterile alpha motif/pointed domain superfamily |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR036116 | Fibronectin type III superfamily |
Domain Details Per Protein
| Protein | Length | Ephrin receptor ligand binding domain | Ephrin receptor, transmembrane domain | Ephrin receptor type-A /type-B | Ephrin receptor tyrosine kinases | Fibronectin type III | Fibronectin type III superfamily | Galactose-binding-like domain superfamily | Immunoglobulin-like fold | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine-threonine/tyrosine-protein kinase, catalytic domain | Sterile alpha motif domain | Sterile alpha motif/pointed domain superfamily | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:O73878
|
976 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
ephb4b-201
(1)
|
Ensembl | 3,731 nt | ||
| mRNA |
ephb4b-202
(1)
|
Ensembl | 2,809 nt |
Interactions and Pathways
No data available
Plasmids
No data available