ZFIN ID: ZDB-GENE-990415-63
Gene Name: eph receptor A2 a
Gene Symbol: epha2a    Nomenclature History

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Previous Names: epha2, id:ibd5152 (1), rtk6

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have transmembrane-ephrin receptor activity. Predicted to be involved in axon guidance and transmembrane receptor protein tyrosine kinase signaling pathway. Predicted to localize to the integral component of plasma membrane; neuron projection; and receptor complex. Human ortholog(s) of this gene implicated in cataract 6 multiple types. Is expressed in tail bud. Orthologous to human EPHA2 (EPH receptor A2).
Genome Resources: Alliance (1),  Gene:30689 (1),  Ensembl(GRCz11):ENSDARG00000017354 (1)
GENE EXPRESSION
Directly Submitted Expression Data: 5 figures (9 images) from Kudoh et al., 2001 [ibd5152]
Wild-type Stages, Structures: Gastrula:Shield (6.0h-8.0h) to Pharyngula:Prim-5 (24.0h-30.0h)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu3575 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la015937Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa1266 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa20802 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa33948 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa33949 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa40777 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44642 Point Mutation Unknown Unknown ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-epha2a N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH epha2a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    cataract 6 multiple types Alliance Cataract 6, multiple types 116600
    DISEASE ASSOCIATED WITH epha2a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process phosphorylation (more)
    Cellular Component integral component of membrane (more)
    Molecular Function ATP binding (more)
    GO Terms (all 20)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Active_site IPR008266 Tyrosine-protein kinase, active site
    Binding_site IPR017441 Protein kinase, ATP binding site
    Conserved_site IPR001426 Tyrosine-protein kinase, receptor class V, conserved site
    Domain IPR000719 Protein kinase domain
    Domain IPR001090 Ephrin receptor ligand binding domain
    Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
    Domain IPR001660 Sterile alpha motif domain
    Domain IPR003961 Fibronectin type III
    Domain IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-like
    Domain IPR020635 Tyrosine-protein kinase, catalytic domain
    Domain IPR027936 Ephrin receptor, transmembrane domain
    Domain IPR034263 Ephrin type-A receptor 2, ligand binding domain
    Family IPR016257 Ephrin receptor type-A /type-B
    Homologous_superfamily IPR008979 Galactose-binding-like domain superfamily
    Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
    Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
    Homologous_superfamily IPR013761 Sterile alpha motif/pointed domain superfamily
    Homologous_superfamily IPR013783 Immunoglobulin-like fold
    Homologous_superfamily IPR036116 Fibronectin type III superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA epha2a-201 (1)    Ensembl 3607
    ncRNA epha2a-002 (1)    Ensembl 638
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM epha2a No data available
    MARKER RELATIONSHIPS
    epha2a Contained in: [BAC] CH73-312E21 (1), DKEY-148L2 (1) (order this)
    epha2a Encodes: [EST] ibd5152 (1)
    [cDNA] MGC:76910 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131415 (1) 3620 nt
    Genomic GenBank:BX663614 (1) 191715 nt
    Select Tool
    Polypeptide UniProtKB:F1QSD6 (1) 984 aa
    Sequence Information (all 15)
    ORTHOLOGY for epha2a ( Chr: 6 )
    CITATIONS (35)