Gene
ephb4a
- ID
- ZDB-GENE-990415-62
- Name
- eph receptor B4a
- Symbol
- ephb4a Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to have ATP binding activity and ephrin receptor activity. Involved in blood vessel morphogenesis; convergent extension; and ephrin receptor signaling pathway. Predicted to localize to integral component of plasma membrane. Is expressed in several structures, including axis; cardiovascular system; digestive system; nervous system; and neural tube. Used to study lymphatic system disease. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human EPHB4 (EPH receptor B4).
- Genome Resources
- Note
- None
- All Expression Data
- 37 figures from 30 publications
- Cross-Species Comparison
- High Throughput Data
- No data available
- Thisse Expression Data
-
- cb646 (39 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Human Disease | Fish | Conditions | Citations |
---|---|---|---|
lymphatic system disease | y1Tg + MO4-ephb4a | standard conditions | Li et al., 2018 |
lymphatic system disease | y1Tg + MO2-ephb4a | standard conditions | Li et al., 2018 |
Domain, Family, and Site Summary
Type | InterPro ID | Name |
---|---|---|
Active_site | IPR008266 | Tyrosine-protein kinase, active site |
Binding_site | IPR017441 | Protein kinase, ATP binding site |
Conserved_site | IPR001426 | Tyrosine-protein kinase, receptor class V, conserved site |
Domain | IPR000719 | Protein kinase domain |
Domain | IPR001090 | Ephrin receptor ligand binding domain |
Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
Domain | IPR001660 | Sterile alpha motif domain |
Domain | IPR003961 | Fibronectin type III |
Domain | IPR011641 | Tyrosine-protein kinase ephrin type A/B receptor-like |
Domain | IPR020635 | Tyrosine-protein kinase, catalytic domain |
Domain | IPR027936 | Ephrin receptor, transmembrane domain |
Domain | IPR034290 | Ephrin type-B receptor 4, ligand binding domain |
Domain | IPR037636 | EPH-B4, SAM domain |
Family | IPR016257 | Ephrin receptor type-A /type-B |
Homologous_superfamily | IPR008979 | Galactose-binding-like domain superfamily |
Homologous_superfamily | IPR009030 | Growth factor receptor cysteine-rich domain superfamily |
Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
Homologous_superfamily | IPR013761 | Sterile alpha motif/pointed domain superfamily |
Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
Homologous_superfamily | IPR036116 | Fibronectin type III superfamily |
Domain Details Per Protein
Protein | Length | EPH-B4, SAM domain | Ephrin receptor ligand binding domain | Ephrin receptor, transmembrane domain | Ephrin receptor type-A /type-B | Ephrin type-B receptor 4, ligand binding domain | Fibronectin type III | Fibronectin type III superfamily | Galactose-binding-like domain superfamily | Growth factor receptor cysteine-rich domain superfamily | Immunoglobulin-like fold | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine-threonine/tyrosine-protein kinase, catalytic domain | Sterile alpha motif domain | Sterile alpha motif/pointed domain superfamily | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain | Tyrosine-protein kinase ephrin type A/B receptor-like | Tyrosine-protein kinase, receptor class V, conserved site |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
UniProtKB:A0A0B5JJY8
|
543 | ||||||||||||||||||||
UniProtKB:A0A0R4IJK3
|
960 | ||||||||||||||||||||
UniProtKB:A9JSS4
|
293 | ||||||||||||||||||||
UniProtKB:A4FUN2
|
293 | ||||||||||||||||||||
UniProtKB:O73875
|
987 | ||||||||||||||||||||
UniProtKB:A0A0R4INV2
|
268 |
Type | Name | Length (nt) | Analysis |
---|---|---|---|
mRNA |
ephb4a-201
(1)
|
2940 nt | |
mRNA |
ephb4a-202
(1)
|
1308 nt |
Interactions and Pathways
No data available
Plasmids
No data available
- Gene Tree
- Ensembl