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ZIRC
ZFIN ID: ZDB-GENE-990415-62
Gene Name: eph receptor B4a
Gene Symbol: ephb4a    Nomenclature History

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Previous Names: ephB4 (1), ephB4a, cb646 (1), rtk5

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have transmembrane-ephrin receptor activity. Involved in convergent extension; ephrin receptor signaling pathway; and vasculature development. Predicted to localize to the integral component of plasma membrane; neuron projection; and receptor complex. Human ortholog(s) of this gene implicated in hereditary lymphedema. Is expressed in several structures, including axis; cardiovascular system; digestive system; nervous system; and neural tube. Orthologous to human EPHB4 (EPH receptor B4).
Genome Resources: Alliance (1),  Gene:30688 (1),  Ensembl(GRCz11):ENSDARG00000100725 (1)
DISEASE ASSOCIATED WITH ephb4a HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Capillary malformation-arteriovenous malformation 2 618196
Lymphatic malformation 7 617300
DISEASE ASSOCIATED WITH ephb4a VIA EXPERIMENTAL MODELS
Human Disease Fish Conditions Citations
lymphatic system disease y1Tg + MO4-ephb4a standard conditions Li et al., 2018
y1Tg + MO2-ephb4a standard conditions Li et al., 2018
GENE ONTOLOGY
Ontology GO Term
Biological Process blood vessel development (more)
Cellular Component integral component of membrane (more)
Molecular Function ATP binding (more)
GO Terms (all 24)
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA ephb4a-201 (1)    Ensembl 2940
ephb4a-202 (1)    Ensembl 1308
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM ephb4a
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(UAS:ephb4a_K662R,cryaa:Cerulean) cryaaUAS Ceruleanephb4a Danio rerio 1 2
MARKER RELATIONSHIPS
ephb4a Contained in: [Fosmid] CH1073-264G23 (1) (order this), ZFOS-1566H6 (1)
ephb4a Contains: [STS] unp162
ephb4a Encodes: [EST] cb646 (1) (order this)
[cDNA] MGC:136748 (1) (order this), MGC:171234 (1) (order this)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_131414 (1) 3055 bp
Genomic GenBank:FO904976 (1) 34139 bp
Select Tool
Polypeptide UniProtKB:O73875 (1) 987 aa
Sequence Clusters UniGene:5764 (1)
Sequence Information (all 37)
ORTHOLOGY for ephb4a ( Chr: 5 )
CITATIONS (92)