Gene

ephb4a

ID
ZDB-GENE-990415-62
Name
eph receptor B4a
Symbol
ephb4a Nomenclature History
Previous Names
  • ephB4 (1)
  • ephB4a
  • cb646 (1)
  • rtk5
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to have ATP binding activity and ephrin receptor activity. Involved in blood vessel morphogenesis; convergent extension; and ephrin receptor signaling pathway. Predicted to localize to integral component of plasma membrane. Is expressed in several structures, including axis; cardiovascular system; digestive system; nervous system; and neural tube. Used to study lymphatic system disease. Human ortholog(s) of this gene implicated in hereditary lymphedema. Orthologous to human EPHB4 (EPH receptor B4).
Genome Resources
Note
None
Expression
All Expression Data
37 figures from 30 publications
Cross-Species Comparison
High Throughput Data
No data available
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
8 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ephb4a Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Capillary malformation-arteriovenous malformation 2 618196
Lymphatic malformation 7 617300
Associated With ephb4a Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008266 Tyrosine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Conserved_site IPR001426 Tyrosine-protein kinase, receptor class V, conserved site
Domain IPR000719 Protein kinase domain
Domain IPR001090 Ephrin receptor ligand binding domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR001660 Sterile alpha motif domain
Domain IPR003961 Fibronectin type III
Domain IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-like
Domain IPR020635 Tyrosine-protein kinase, catalytic domain
Domain IPR027936 Ephrin receptor, transmembrane domain
Domain IPR034290 Ephrin type-B receptor 4, ligand binding domain
Domain IPR037636 EPH-B4, SAM domain
Family IPR016257 Ephrin receptor type-A /type-B
Homologous_superfamily IPR008979 Galactose-binding-like domain superfamily
Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR013761 Sterile alpha motif/pointed domain superfamily
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR036116 Fibronectin type III superfamily
Domain Details Per Protein
Protein Length EPH-B4, SAM domain Ephrin receptor ligand binding domain Ephrin receptor, transmembrane domain Ephrin receptor type-A /type-B Ephrin type-B receptor 4, ligand binding domain Fibronectin type III Fibronectin type III superfamily Galactose-binding-like domain superfamily Growth factor receptor cysteine-rich domain superfamily Immunoglobulin-like fold Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine-threonine/tyrosine-protein kinase, catalytic domain Sterile alpha motif domain Sterile alpha motif/pointed domain superfamily Tyrosine-protein kinase, active site Tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase ephrin type A/B receptor-like Tyrosine-protein kinase, receptor class V, conserved site
UniProtKB:A0A0B5JJY8 543
UniProtKB:A0A0R4IJK3 960
UniProtKB:A9JSS4 293
UniProtKB:A4FUN2 293
UniProtKB:O73875 987
UniProtKB:A0A0R4INV2 268
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations