ZFIN ID: ZDB-GENE-990415-62
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Gene Name: eph receptor B4a
Gene Symbol: ephb4a
Sequence Ontology ID : SO:0000704

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Previous Names: ephB4 (1), ephB4a, cb646 (1), rtk5

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(Including Attributions)
Location: Chr: 5 Mapping Details/Browsers
AUTOMATED DESCRIPTION
Predicted to have transmembrane-ephrin receptor activity; involved in angioblast cell migration involved in selective angioblast sprouting, convergent extension, and ephrin receptor signaling  ...
GENE EXPRESSION
All Expression Data: 33 figures from 27 publications
Directly Submitted Expression Data: 6 figures (39 images) from Thisse et al., 2001 [cb646]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Hatching:Long-pec (48.0h-60.0h)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu3378 Unknown Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
    • hu3445 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
    • la015774Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
    • la025269Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa11431 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa13275 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa30869 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa33770 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • Targeting reagents:
    PHENOTYPE
    Data: 8 figures from 5 publications
    Observed in:
    DISEASE ASSOCIATED WITH ephb4a HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Lymphatic malformation 7 617300
    Lymphatic malformation 7 617300
    Capillary malformation-arteriovenous malformation 2 618196
    Capillary malformation-arteriovenous malformation 2 618196
    DISEASE ASSOCIATED WITH ephb4a VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    lymphatic system disease y1Tg + MO4-ephb4a standard conditions Li et al., 2018
    y1Tg + MO2-ephb4a standard conditions Li et al., 2018
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process blood vessel development (more)
    Cellular Component integral component of membrane (more)
    Molecular Function ATP binding (more)
    GO Terms (all 20)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000719 (1)
  • InterPro:IPR001090 (1)
  • InterPro:IPR001245 (1)
  • InterPro:IPR001426 (1)
  • InterPro:IPR001660 (1)
  • InterPro:IPR003961 (1)
  • InterPro:IPR008266 (1)
  • InterPro:IPR008979 (1)
  • InterPro:IPR009030 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR011641 (1)
  • InterPro:IPR013761 (1)
  • InterPro:IPR013783 (1)
  • InterPro:IPR016257 (1)
  • InterPro:IPR017441 (1)
  • InterPro:IPR020635 (1)
  • InterPro:IPR027936 (1)
  • InterPro:IPR034290 (1)
  • InterPro:IPR036116 (1)
  • InterPro:IPR037636 (1)
    		•
  • PROSITE:PS00107 (1)
  • PROSITE:PS00109 (1)
  • PROSITE:PS00791 (1)
  • PROSITE:PS50011 (1)
  • PROSITE:PS50105 (1)
  • PROSITE:PS50853 (1)
  • PROSITE:PS51550 (1)
    		•
  • Pfam:PF00041 (1)
  • Pfam:PF00536 (1)
  • Pfam:PF01404 (1)
  • Pfam:PF07714 (1)
  • Pfam:PF14575 (1)
    		•
  • EC:2.7.10.1 (1)
    		•
    TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA ephb4a-201 (1) 2940
    Select Tool
    ephb4a-202 (1) 1308
    Select Tool
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM ephb4a
    MARKER RELATIONSHIPS
    ephb4aContained in: [Fosmid] CH1073-264G23 (1) (order this), ZFOS-1566H6 (1)
    ephb4aContains: [STS] unp162
    ephb4aEncodes: [EST] cb646 (1) (order this)
    [cDNA] MGC:136748 (1) (order this), MGC:171234 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131414 (1) 3055bp
    Select Tool
    Genomic GenBank:FO904976 (1) 34139bp
    Select Tool
    Polypeptide UniProtKB:A0A2R8QG60 (1) 987aa
    Select Tool
    Sequence Clusters UniGene:5764 (1)
    Sequence Information (all 37)
    OTHER ephb4a GENE PAGES
  • Alliance (1)
  • Gene:30688 (1)
  • VEGA:OTTDARG00000029266 (1)
  • Ensembl(GRCz11):ENSDARG00000100725 (1)
    • ORTHOLOGY for ephb4a (Chr: 5)
    CITATIONS (86)