| ZFIN ID: ZDB-GENE-990415-62 |
| Gene Name: | eph receptor B4a | |||||||||||||
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| Gene Symbol: | ephb4a Nomenclature History |
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Attributions
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| Previous Names: | ephB4 (1), ephB4a, cb646 (1), rtk5 | |||||||||||||
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| Gene Type: | protein_coding_gene | |||||||||||||
| Location: | Chr: 5 Mapping Details/Browsers | |||||||||||||
| Description: | Predicted to have transmembrane-ephrin receptor activity. Involved in convergent extension; ephrin receptor signaling pathway; and vasculature development. Predicted to localize to the integral component of plasma membrane; neuron projection; and receptor complex. Human ortholog(s) of this gene implicated in hereditary lymphedema. Is expressed in several structures, including axis; cardiovascular system; digestive system; nervous system; and neural tube. Orthologous to human EPHB4 (EPH receptor B4). | |||||||||||||
| Genome Resources: | Alliance (1), Gene:30688 (1), Ensembl(GRCz11):ENSDARG00000100725 (1) | |||||||||||||
| All Expression Data: | 34 figures from 28 publications |
| Directly Submitted Expression Data: | 6 figures (39 images) from Thisse et al., 2001 [cb646] |
| Wild-type Stages, Structures: | Gastrula:50%-epiboly (5.25h-5.66h) to Hatching:Long-pec (48.0h-60.0h) |
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| Curated Microarray Expression: | GEO (1) |
| Targeting Reagent | Created Alleles | Publications |
|---|---|---|
| MO1-ephb4a | N/A | 2 |
| MO2-ephb4a | N/A | 2 |
| MO3-ephb4a | N/A | 2 |
| MO4-ephb4a | N/A | 1 |
| Data: | 8 figures from 5 publications |
| Observed in: |
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| lymphatic system disease | y1Tg + MO4-ephb4a | standard conditions | Li et al., 2018 |
| y1Tg + MO2-ephb4a | standard conditions | Li et al., 2018 |
| Ontology | GO Term |
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| Biological Process | blood vessel development (more) |
| Cellular Component | integral component of membrane (more) |
| Molecular Function | ATP binding (more) |
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| Type | Name | Length (nt) | Analysis | |
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| mRNA |
ephb4a-201
(1)
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2940 |
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ephb4a-202
(1)
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1308 |
Select Tool
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| Browsers: UCSC, NCBI, Ensembl, ZFIN |
| ephb4a Contained in: | [Fosmid] CH1073-264G23 (1) (order this), ZFOS-1566H6 (1) |
| ephb4a Contains: | [STS] unp162 |
| ephb4a Encodes: |
[EST]
cb646 (1) (order this)
[cDNA] MGC:136748 (1) (order this), MGC:171234 (1) (order this) |
| Type | Accession # | Length (bp/aa) | Analysis |
|---|---|---|---|
| RNA | RefSeq:NM_131414 (1) | 3055 bp |
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| Genomic | GenBank:FO904976 (1) | 34139 bp | |
| Polypeptide | UniProtKB:O73875 (1) | 987 aa |
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| Sequence Clusters | UniGene:5764 (1) |
