ZFIN ID: ZDB-GENE-990415-62
Gene Name: eph receptor B4a
Gene Symbol: ephb4a    Nomenclature History

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Previous Names: ephB4 (1), ephB4a, cb646 (1), rtk5

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have transmembrane-ephrin receptor activity. Involved in convergent extension; ephrin receptor signaling pathway; and vasculature development. Predicted to localize to the integral component of plasma membrane; neuron projection; and receptor complex. Human ortholog(s) of this gene implicated in hereditary lymphedema. Is expressed in several structures, including axis; cardiovascular system; digestive system; nervous system; and neural tube. Orthologous to human EPHB4 (EPH receptor B4).
Genome Resources: Alliance (1),  Gene:30688 (1),  Ensembl(GRCz11):ENSDARG00000100725 (1)
DISEASE ASSOCIATED WITH ephb4a HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Capillary malformation-arteriovenous malformation 2 618196
Lymphatic malformation 7 617300
DISEASE ASSOCIATED WITH ephb4a VIA EXPERIMENTAL MODELS
Human Disease Fish Conditions Citations
lymphatic system disease y1Tg + MO4-ephb4a standard conditions Li et al., 2018
y1Tg + MO2-ephb4a standard conditions Li et al., 2018
GENE ONTOLOGY
Ontology GO Term
Biological Process blood vessel development (more)
Cellular Component integral component of membrane (more)
Molecular Function ATP binding (more)
GO Terms (all 24)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Active_site IPR008266 Tyrosine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Conserved_site IPR001426 Tyrosine-protein kinase, receptor class V, conserved site
Domain IPR000719 Protein kinase domain
Domain IPR001090 Ephrin receptor ligand binding domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR001660 Sterile alpha motif domain
Domain IPR003961 Fibronectin type III
Domain IPR011641 Tyrosine-protein kinase ephrin type A/B receptor-like
Domain IPR020635 Tyrosine-protein kinase, catalytic domain
Domain IPR027936 Ephrin receptor, transmembrane domain
Domain IPR034290 Ephrin type-B receptor 4, ligand binding domain
Domain IPR037636 EPH-B4, SAM domain
Family IPR016257 Ephrin receptor type-A /type-B
Homologous_superfamily IPR008979 Galactose-binding-like domain superfamily
Homologous_superfamily IPR009030 Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR013761 Sterile alpha motif/pointed domain superfamily
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR036116 Fibronectin type III superfamily
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA ephb4a-201 (1)    Ensembl 2940
ephb4a-202 (1)    Ensembl 1308
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM ephb4a
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(UAS:ephb4a_K662R,cryaa:Cerulean) cryaaUAS Ceruleanephb4a Danio rerio 1 2
MARKER RELATIONSHIPS
ephb4a Contained in: [Fosmid] CH1073-264G23 (1), ZFOS-1566H6 (1)
ephb4a Contains: [STS] unp162
ephb4a Encodes: [EST] cb646 (1) (order this)
[cDNA] MGC:136748 (1), MGC:171234 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_131414 (1) 3055 nt
Genomic GenBank:FO904976 (1) 34139 nt
Select Tool
Polypeptide UniProtKB:O73875 (1) 987 aa
Sequence Information (all 36)
ORTHOLOGY for ephb4a ( Chr: 5 )
CITATIONS (94)