ZFIN ID: ZDB-GENE-990415-56
Gene Name: TEK tyrosine kinase, endothelial
Gene Symbol: tek
Sequence Ontology ID : SO:0000704

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Previous Names: tie-2, tie2 (1)

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(Including Attributions)
Location: Chr: 5 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have transmembrane receptor protein tyrosine kinase activity; involved in angiogenesis and heart development; predicted to localize to the cytoplasm, integral component of plasma  ...
GENE EXPRESSION
All Expression Data: 28 figures from 26 publications
Wild-type Stages, Structures: Cleavage:4-cell (1.0h-1.25h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu1667 Point Mutation Unknown Premature Stop
Targeting reagents:
PHENOTYPE
Data: 3 figures from Li et al., 2014
Observed in:
DISEASE ASSOCIATED WITH tek HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
multiple cutaneous and mucosal venous malformations Venous malformations, multiple cutaneous and mucosal 600195
Glaucoma 3, primary congenital, E 617272
DISEASE ASSOCIATED WITH tek VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process angiogenesis (more)
Cellular Component cell junction (more)
Molecular Function ATP binding (more)
GO Terms (all 20)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000719 (1)
  • InterPro:IPR000742 (1)
  • InterPro:IPR001245 (1)
  • InterPro:IPR003599 (1)
  • InterPro:IPR003961 (1)
  • InterPro:IPR007110 (1)
  • InterPro:IPR008266 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR013032 (1)
  • InterPro:IPR013098 (1)
  • InterPro:IPR013783 (1)
  • InterPro:IPR017441 (1)
  • InterPro:IPR018941 (1)
  • InterPro:IPR020635 (1)
  • InterPro:IPR036116 (1)
  • InterPro:IPR036179 (1)
  • PROSITE:PS00022 (1)
  • PROSITE:PS00107 (1)
  • PROSITE:PS00109 (1)
  • PROSITE:PS01186 (1)
  • PROSITE:PS50011 (1)
  • PROSITE:PS50026 (1)
  • PROSITE:PS50835 (1)
  • PROSITE:PS50853 (1)
  • Pfam:PF00041 (1)
  • Pfam:PF07679 (1)
  • Pfam:PF07714 (1)
  • Pfam:PF10430 (1)
  • EC:2.7.10.1 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA tek-002 (1) 560
    tek-202 (1) 3436
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    PLASMIDS
    Addgene
    CONSTRUCTS WITH SEQUENCES FROM tek No data available
    MARKER RELATIONSHIPS
    tekContained in: [BAC] DKEY-87D21 (1) (order this)
    tekEncodes: [cDNA] MGC:195221 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131461 (1) 3601bp
    Genomic GenBank:CU855580 (1) 50040bp
    Select Tool
    Polypeptide UniProtKB:B3DJR6 (1) 1116aa
    Sequence Clusters UniGene:75820 (1)
    Sequence Information (all 22)
    OTHER tek GENE PAGES
  • Alliance (1)
  • Gene:30747 (1)
  • VEGA:OTTDARG00000033993 (1)
  • Ensembl(GRCz11):ENSDARG00000028663 (2)
  • ORTHOLOGY for tek (Chr: 5)
    CITATIONS (92)