ZFIN ID: ZDB-GENE-990415-56
Gene Name: TEK tyrosine kinase, endothelial
Gene Symbol: tek    Nomenclature History

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Previous Names: tie-2, tie2 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 5 Mapping Details/Browsers
Description: Predicted to have transmembrane receptor protein tyrosine kinase activity. Involved in angiogenesis and heart development. Predicted to localize to the integral component of plasma membrane and receptor complex. Human ortholog(s) of this gene implicated in arteriovenous malformation and multiple cutaneous and mucosal venous malformations. Is expressed in endothelial cell; vasculature; and vertical myoseptum. Orthologous to human TEK (TEK receptor tyrosine kinase).
Genome Resources: Alliance (1),  Gene:30747 (1),  Ensembl(GRCz11):ENSDARG00000028663 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu1667 Point Mutation Unknown Premature Stop
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-tek N/A 1
DISEASE ASSOCIATED WITH tek HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
multiple cutaneous and mucosal venous malformations Alliance Venous malformations, multiple cutaneous and mucosal 600195
Glaucoma 3, primary congenital, E 617272
DISEASE ASSOCIATED WITH tek VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process angiogenesis (more)
Cellular Component cell junction (more)
Molecular Function ATP binding (more)
GO Terms (all 28)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Domain IPR000719 Protein kinase domain
Domain IPR000742 EGF-like domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR003599 Immunoglobulin subtype
Domain IPR003961 Fibronectin type III
Domain IPR007110 Immunoglobulin-like domain
Active_site IPR008266 Tyrosine-protein kinase, active site
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Conserved_site IPR013032 EGF-like, conserved site
Domain IPR013098 Immunoglobulin I-set
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR018941 Tyrosine-protein kinase, receptor Tie-2, Ig-like domain 1, N-terminal
Domain IPR020635 Tyrosine-protein kinase, catalytic domain
Homologous_superfamily IPR036116 Fibronectin type III superfamily
Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA tek-002 (1) 560
tek-202 (1)    Ensembl 3436
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-tek monoclonal IgG Mouse IHC R&D Systems
3
CONSTRUCTS WITH SEQUENCES FROM tek No data available
MARKER RELATIONSHIPS
tek Contained in: [BAC] DKEY-87D21 (1) (order this)
tek Encodes: [cDNA] MGC:195221 (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_131461 (1) 3601 bp
Genomic GenBank:CU855580 (1) 50040 bp
Select Tool
Polypeptide UniProtKB:B3DJR6 (1) 1116 aa
Sequence Information (all 21)
ORTHOLOGY for tek ( Chr: 5 )
CITATIONS (94)