Gene

tcf3a

ID

ZDB-GENE-990415-51

Name

transcription factor 3a

Symbol

tcf3a Nomenclature History

Previous Names

tcf3
Tcf3b (1)
e12
E2A (1)
zfe12 (1)
zgc:113926

Type

protein_coding_gene

Location

Chr: 2 Mapping Details/Browsers

Description

Exhibits sequence-specific DNA binding activity. Involved in striated muscle cell development. Predicted to localize to nucleus and transcription factor complex. Human ortholog(s) of this gene implicated in agammaglobulinemia and colorectal cancer. Orthologous to human TCF3 (transcription factor 3).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

6 figures from 6 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

IMAGE:7140653 (1 image)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 1 Figure from Chong et al., 2007
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tcf3a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
agammaglobulinemia 8A	Alliance	Agammaglobulinemia 8A, autosomal dominant	616941
agammaglobulinemia 8B	Alliance	Agammaglobulinemia 8B, autosomal recessive	619824

Associated With tcf3a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR011598	Myc-type, basic helix-loop-helix (bHLH) domain
Homologous_superfamily	IPR036638	Helix-loop-helix DNA-binding domain superfamily

Domain Details Per Protein

Protein	Length	Helix-loop-helix DNA-binding domain superfamily	Myc-type, basic helix-loop-helix (bHLH) domain
UniProtKB:Q90491 InterPro	583

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	tcf3a-202 (1) Ensembl	Havana	763 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	tcf3a-203 (1) Ensembl	Havana	1197 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	tcf3a-003 (1) Ensembl	Havana	489 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
ncRNA	tcf3a-004 (1) Ensembl	Havana	799 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations