ZFIN ID: ZDB-GENE-990415-39
Gene Name: growth differentiation factor 5
Gene Symbol: gdf5    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: bmp14 (1), contact (1), ctc (1), e1gdf5

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Predicted to have cytokine activity. Predicted to be involved in BMP signaling pathway; SMAD protein signal transduction; and positive regulation of pathway-restricted SMAD protein phosphorylation. Predicted to localize to extracellular space. Human ortholog(s) of this gene implicated in Parkinson's disease; bone development disease (multiple); osteoarthritis; and proximal symphalangism. Is expressed in perichondrium; pharynx; and skeletal system. Orthologous to human GDF5 (growth differentiation factor 5).
Genome Resources: Alliance (1),  Gene:100334210 (1),  Ensembl(GRCz11):ENSDARG00000002760 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa10139 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH gdf5 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    acromesomelic dysplasia, Grebe type Alliance Chondrodysplasia, Grebe type 200700
    acromesomelic dysplasia, Hunter-Thompson type Alliance ?Acromesomelic dysplasia, Hunter-Thompson type 201250
    brachydactyly type A1C Alliance Brachydactyly, type A1, C 615072
    brachydactyly type A2 Alliance Brachydactyly, type A2 112600
    brachydactyly type C Alliance Brachydactyly, type C 113100
    fibular hypoplasia and complex brachydactyly Alliance Du Pan syndrome 228900
    multiple synostoses syndrome Alliance Multiple synostoses syndrome 2 610017
    Symphalangism, proximal, 1B 615298
    {Osteoarthritis-5} 612400
    DISEASE ASSOCIATED WITH gdf5 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process BMP signaling pathway (more)
    Cellular Component extracellular region (more)
    Molecular Function growth factor activity (more)
    GO Terms (all 7)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA gdf5-201 (1)    Ensembl 1922
    gdf5-202 (1)    Ensembl 1848
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gdf5 No data available
    MARKER RELATIONSHIPS
    gdf5 Contained in: [BAC] CH73-166O16 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_002662541 (1)
    Genomic GenBank:CU463256 (1) 54185 nt
    Select Tool
    Polypeptide UniProtKB:F1QK08 (1) 474 aa
    Sequence Information (all 10)
    ORTHOLOGY for gdf5 ( Chr: 6 )
    CITATIONS (34)