ZFIN ID: ZDB-GENE-990415-35
Gene Name: complement component c3a, duplicate 1
Gene Symbol: c3a.1    Nomenclature History

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Previous Names: C3-1 (1), c3.1 (1), c3a, cb26 (1), sb:cb26 (1), si:dkey-76b14.4, wu:fi34b03, wu:fj86e11

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to have endopeptidase inhibitor activity. Involved in chordate embryonic development. Predicted to localize to extracellular space. Is expressed in several structures, including gill; heart; liver; pleuroperitoneal region; and yolk syncytial layer. Human ortholog(s) of this gene implicated in several diseases, including complement deficiency (multiple); macular degeneration (multiple); paroxysmal nocturnal hemoglobinuria; sickle cell anemia; and silicosis. Orthologous to human C3 (complement C3).
Genome Resources: Alliance (1),  Gene:321046 (1),  Ensembl(GRCz11):ENSDARG00000012694 (2)
GENE EXPRESSION
All Expression Data: 19 figures from 7 publications
Directly Submitted Expression Data: 5 figures (3 images) from Thisse et al., 2001 [cb26]
  7 figures (10 images) from Thisse et al., 2004 [IMAGE:7148060]
Wild-type Stages, Structures: Segmentation:14-19 somites (16.0h-19.0h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa1745 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa8557 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa10419 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa18656 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa19621 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa31241 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa31242 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32790 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39715 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zko1158a Small Deletion Unknown Unknown CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-c3a.1 1
    MO1-c3a N/A 1
    MO1-c3a.1 N/A 1
    DISEASE ASSOCIATED WITH c3a.1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    age related macular degeneration 9 Alliance {Macular degeneration, age-related, 9} 611378
    complement component 3 deficiency Alliance C3 deficiency 613779
    {Hemolytic uremic syndrome, atypical, susceptibility to, 5} 612925
    DISEASE ASSOCIATED WITH c3a.1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process chordate embryonic development (more)
    Cellular Component extracellular region (more)
    Molecular Function endopeptidase inhibitor activity (more)
    GO Terms (all 5)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA c3a.1-201 (1)    Ensembl 5069
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM c3a.1 No data available
    MARKER RELATIONSHIPS
    c3a.1 Contained in: [BAC] DKEY-76B14 (1) (order this)
    c3a.1 Encodes: [EST] cb26 (1) (order this), fi34b03, fj86e11, IMAGE:7148060 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131242 (1)
    Genomic GenBank:CU280887 (1) 132186 nt
    Select Tool
    Polypeptide UniProtKB:B8JKW4 (1) 1643 aa
    Sequence Information (all 32)
    ORTHOLOGY for c3a.1 ( Chr: 1 )
    CITATIONS (50)