ZFIN ID: ZDB-GENE-990415-30
Gene Name: activated leukocyte cell adhesion molecule a
Gene Symbol: alcama    Nomenclature History

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Previous Names: alcam (1), cd166 (1), DM-GRASP (1), neurolin-a (1), neurolin (1), zn5 / zn-5 antigen (1), zn8 / zn-8 antigen

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Exhibits identical protein binding activity. Involved in several processes, including animal organ morphogenesis; neural crest cell differentiation; and positive regulation of cell morphogenesis involved in differentiation. Localizes to axon. Is expressed in several structures, including digestive system; immature eye; musculature system; nervous system; and pericardial region. Orthologous to human ALCAM (activated leukocyte cell adhesion molecule).
Genome Resources: Alliance (1),  Gene:30194 (1),  Ensembl(GRCz11):ENSDARG00000026531 (1)
GENE EXPRESSION
All Expression Data: 171 figures from 99 publications
Directly Submitted Expression Data: 6 figures (14 images) from Thisse et al., 2004 [MGC:55230]
Wild-type Stages, Structures: Segmentation:1-4 somites (10.33h-11.66h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
bns201 Small Deletion Exon 10 Unknown TALEN
bns244 Small Deletion Promoter Unknown CRISPR
la011841Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12510 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34926 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-alcama 1
    CRISPR2-alcama 1
    MO1-alcama N/A 2
    MO2-alcama N/A 1
    MO3-alcama N/A 2
    MO4-alcama N/A 1
    MO5-alcama N/A 1
    DISEASE ASSOCIATED WITH alcama HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH alcama VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process axonogenesis (more)
    Cellular Component axon (more)
    Molecular Function identical protein binding (more)
    GO Terms (all 20)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA alcama-201 (1)    Ensembl 3112
    ottdart00000004183 (1) 1145
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab2-alcama polyclonal Rabbit IHC 4
    zn-5 monoclonal IgG1 , k Mouse IHC, WB Zebrafish International Resource Center (ZIRC)  (order this)
    211
    Ab3-alcama monoclonal Mouse IHC 3
    Ab1-alcama monoclonal IgG Mouse WB 2
    zn-8 monoclonal IgG1 , k Mouse IHC Developmental Studies Hybridoma Bank
    Zebrafish International Resource Center (ZIRC)  (order this)
    163
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM alcama
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(nkx2.3:alcama-EGFP) nkx2.3 alcamaEGFP Danio rerio 1 3
    MARKER RELATIONSHIPS
    alcama Contained in: [BAC] DKEY-222J15 (1) (order this)
    [PAC] BUSM1-17K08 (1), BUSM1-25N23 (1), BUSM1-39L02 (1), BUSM1-71O15 (1)
    alcama Encodes: [cDNA] cssl:d215 (1), cssl:d822 (1), MGC:55230 (1), MGC:85602 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131000 (1) 2057 nt
    Genomic GenBank:BX537347 (1) 197064 nt
    Select Tool
    Polypeptide UniProtKB:A0A2R8RU51 (1) 564 aa
    Sequence Information (all 45)
    ORTHOLOGY for alcama ( Chr: 10 )
    CITATIONS (160)