ZFIN ID: ZDB-GENE-990415-263
Gene Name: thyroid hormone receptor alpha a
Gene Symbol: thraa    Nomenclature History

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Previous Names: thra, thral, TR[a]1 (1), tra1, tra, c-erbA (1), NR1A1-A (1), nr1a1, nr1a1a (1), wu:fb59g07

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Exhibits nuclear receptor activity. Involved in regulation of transcription by RNA polymerase II; thyroid hormone mediated signaling pathway; and ventricular system development. Localizes to the nucleus. Used to study hypothyroidism. Human ortholog(s) of this gene implicated in congenital nongoitrous hypothyroidism 6 and renal cell carcinoma. Is expressed in several structures, including blastodisc; muscle; nervous system; optic cup; and pleuroperitoneal region. Orthologous to human THRA (thyroid hormone receptor alpha).
Genome Resources: Alliance (1),  Gene:30670 (1),  Ensembl(GRCz11):ENSDARG00000000151 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la015187Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa25254 Point Mutation Unknown Premature Stop ENU
    sa31341 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa31342 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-thraa
    1
    CRISPR2-thraa
    1
    MO1-thraa N/A 1
    MO2-thraa N/A 1
    MO3-thraa N/A 1
    MO4-thraa N/A 1
    DISEASE ASSOCIATED WITH thraa HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    congenital nongoitrous hypothyroidism 6 Alliance Hypothyroidism, congenital, nongoitrous, 6 614450
    DISEASE ASSOCIATED WITH thraa VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    hypothyroidism AB + MO4-thraa standard conditions Marelli et al., 2016
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process negative regulation of transcription, DNA-templated (more)
    Cellular Component nucleus (more)
    Molecular Function nuclear receptor activity (more)
    GO Terms (all 34)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000536 Nuclear hormone receptor, ligand-binding domain
    Domain IPR001628 Zinc finger, nuclear hormone receptor-type
    Family IPR001723 Nuclear hormone receptor
    Family IPR001728 Thyroid hormone receptor
    Homologous_superfamily IPR013088 Zinc finger, NHR/GATA-type
    Homologous_superfamily IPR035500 Nuclear hormone receptor-like domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA thraa-201 (1)    Ensembl 2292
    thraa-202 (1)    Ensembl 1470
    ncRNA thraa-003 (1)    Ensembl 651
    thraa-004 (1)    Ensembl 334
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM thraa No data available
    MARKER RELATIONSHIPS
    thraa Contained in: [BAC] RP71-18K17 (1)
    thraa Encodes: [EST] fb59g07 (1), u54796 (2)
    [cDNA] MGC:109800 (1), MGC:191904 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131396 (1) 2200 bp
    Genomic GenBank:AL590145 (1) 135675 bp
    Select Tool
    Polypeptide UniProtKB:B2GQG7 (1) 427 aa
    Sequence Information (all 37)
    ORTHOLOGY for thraa ( Chr: 3 )
    CITATIONS (151)