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ZIRC
ZFIN ID: ZDB-GENE-990415-263
Gene Name: thyroid hormone receptor alpha a
Gene Symbol: thraa    Nomenclature History

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Previous Names: thra, thral, TR[a]1 (1), tra1, tra, c-erbA (1), NR1A1-A (1), nr1a1, nr1a1a (1), wu:fb59g07

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 3 Mapping Details/Browsers
Description: Exhibits nuclear receptor activity. Involved in regulation of transcription by RNA polymerase II; thyroid hormone mediated signaling pathway; and ventricular system development. Localizes to the nucleus. Used to study hypothyroidism. Human ortholog(s) of this gene implicated in congenital nongoitrous hypothyroidism 6 and renal cell carcinoma. Is expressed in several structures, including blastodisc; muscle; nervous system; optic cup; and pleuroperitoneal region. Orthologous to human THRA (thyroid hormone receptor alpha).
Genome Resources: Alliance (1),  Gene:30670 (1),  Ensembl(GRCz11):ENSDARG00000000151 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la015187Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa25254 Point Mutation Unknown Premature Stop ENU
    sa31341 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa31342 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-thraa
    1
    MO1-thraa N/A 1
    MO2-thraa N/A 1
    MO3-thraa N/A 1
    MO4-thraa N/A 1
    DISEASE ASSOCIATED WITH thraa HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    congenital nongoitrous hypothyroidism 6 Alliance Hypothyroidism, congenital, nongoitrous, 6 614450
    DISEASE ASSOCIATED WITH thraa VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    hypothyroidism AB + MO4-thraa standard conditions Marelli et al., 2016
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process negative regulation of transcription, DNA-templated (more)
    Cellular Component nucleus (more)
    Molecular Function nuclear receptor activity (more)
    GO Terms (all 34)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA thraa-201 (1)    Ensembl 2292
    thraa-202 (1)    Ensembl 1470
    ncRNA thraa-003 (1)    Ensembl 651
    thraa-004 (1)    Ensembl 334
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM thraa No data available
    MARKER RELATIONSHIPS
    thraa Contained in: [BAC] RP71-18K17 (1) (order this)
    thraa Encodes: [EST] fb59g07 (1), u54796 (2) (order this)
    [cDNA] MGC:109800 (1) (order this), MGC:191904 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131396 (1) 2200 bp
    Genomic GenBank:AL590145 (1) 135675 bp
    Select Tool
    Polypeptide UniProtKB:B2GQG7 (1) 427 aa
    Sequence Clusters UniGene:75070 (1)
    Sequence Information (all 38)
    ORTHOLOGY for thraa ( Chr: 3 )
    CITATIONS (147)