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ZIRC
ZFIN ID: ZDB-GENE-990415-256
Gene Name: nodal-related 1
Gene Symbol: ndr1    Nomenclature History

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Previous Names: Ndr-1, CHUNP6892, sqt, squint, Znr-2, znr2

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have cytokine activity; transforming growth factor beta receptor binding activity; and type I activin receptor binding activity. Involved in several processes, including animal organ development; positive regulation of fibroblast growth factor receptor signaling pathway; and regionalization. Localizes to the protein-containing complex. Human ortholog(s) of this gene implicated in visceral heterotaxy. Is expressed in embryonic structure; ovary; posterior lateral line primordium; and unfertilized egg. Orthologous to human NODAL (nodal growth differentiation factor).
Genome Resources: Alliance (1),  Gene:799352 (1),  Ensembl(GRCz11):ENSDARG00000057096 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
cz35 Insertion Unknown Unknown
  • Zebrafish International Resource Center (ZIRC) (order this)
  • hi975Tg Transgenic Insertion Exon 2 Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la021868Tg Transgenic Insertion Unknown Unknown DNA
    ndr1_unspecified Unspecified Unknown Unknown
    sg7 Insertion Unknown Unknown ZINC_FINGER_NUCLEASE
    sg27 Indel Unknown Unknown TALEN
    sg32 Indel Unknown Unknown TALEN
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-ndr1
    2
    CRISPR2-ndr1
    1
    CRISPR3-ndr1
    1
    CRISPR4-ndr1
    1
    CRISPR5-ndr1
    1
    CRISPR6-ndr1
    1
    CRISPR7-ndr1
    1
    MO1-ndr1 N/A 3
    MO2-ndr1 N/A 3
    MO3-ndr1 N/A 2
    MO4-ndr1 N/A 14
    MO5-ndr1 N/A 2
    MO6-ndr1 N/A 2
    TALEN1-ndr1 1
    TALEN2-ndr1 1
    DISEASE ASSOCIATED WITH ndr1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    situs inversus Alliance Heterotaxy, visceral, 5 270100
    DISEASE ASSOCIATED WITH ndr1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process determination of dorsal identity (more)
    Cellular Component protein-containing complex (more)
    Molecular Function growth factor activity (more)
    GO Terms (all 24)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ndr1-201 (1)    Ensembl 1592
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ndr1
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(ndr1:GFP) ndr1 GFP Danio rerio 1 2
    Tg(UAS:ndr1-UTRnanos3) UAS nanos3ndr1UTR Danio rerio 1 1
    MARKER RELATIONSHIPS
    ndr1 Contained in: [BAC] CH211-220B15 (order this), CH211-263M18 (1) (order this)
    ndr1 Contains: [SNP] rs3729101 (1), rs3729102 (1)
    ndr1 Encodes: [BAC END] zk5k12.sp6
    [cDNA] MGC:114021 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_130966 (1) 1480 bp
    Genomic GenBank:AL954771 197721 bp
    Select Tool
    Polypeptide UniProtKB:F1QDT8 (1) 392 aa
    Sequence Clusters UniGene:20960 (1)
    Sequence Information (all 20)
    ORTHOLOGY for ndr1 ( Chr: 21 )
    CITATIONS (215)