ZFIN ID: ZDB-GENE-990415-223
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Gene Name: frizzled class receptor 7a
Gene Symbol: fzd7a    Nomenclature History

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Previous Names: fz7, zg07, id:ibd2735 (1), wu:fc17e10

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 9 Mapping Details/Browsers
Description: Predicted to have Wnt-activated receptor activity and Wnt-protein binding activity. Involved in chondrocyte proliferation; epiboly; and gastrulation. Localizes to the plasma membrane. Is expressed in several structures, including margin; mesenchyme; nervous system; neural tube; and pharyngeal arch. Orthologous to human FZD7 (frizzled class receptor 7).
Genome Resources: Alliance (1),  Gene:30369 (1),  Ensembl(GRCz11):ENSDARG00000060004 (1)
GENE EXPRESSION
All Expression Data: 32 figures from 11 publications
Directly Submitted Expression Data: 6 figures (20 images) from Thisse et al., 2004 [MGC:85603]
  3 figures (4 images) from Kudoh et al., 2001 [ibd2735]
  7 figures (17 images) from Thisse et al., 2005 [eu262]
Wild-type Stages, Structures: Blastula:30%-epiboly (4.66h-5.25h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
e3 Point Mutation Unknown Premature Stop ENU
sa10339 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sdu5 Indel Exon 1 Unknown TALEN
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-fzd7a N/A 3
    MO2-fzd7a N/A 1
    TALEN1-fzd7a 1
    PHENOTYPE
    Data: 11 figures from 2 publications
    Observed in:
    DISEASE ASSOCIATED WITH fzd7a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH fzd7a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process convergent extension involved in gastrulation (more)
    Cellular Component plasma membrane (more)
    Molecular Function transmembrane signaling receptor activity (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000539 Frizzled/Smoothened, transmembrane domain
    Domain IPR017981 GPCR, family 2-like
    Domain IPR020067 Frizzled domain
    Family IPR015526 Frizzled/secreted frizzled-related protein
    Family IPR026552 Frizzled-7
    Homologous_superfamily IPR036790 Frizzled cysteine-rich domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA fzd7a-201 (1)    Ensembl 2764
    Select Tool
    Browsers: UCSC,  NCBI,  Ensembl,  ZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM fzd7a No data available
    MARKER RELATIONSHIPS
    fzd7a Contained in: [BAC] DKEY-62A12 (1) (order this)
    fzd7a Encodes: [EST] eu262 (1), fc17e10, ibd2735 (1)
    [cDNA] MGC:65759 (1), MGC:85603 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131139 (1) 2768 nt
    Select Tool
    Genomic GenBank:CR407547 (1) 204067 nt Blast at MegaBLAST
    Polypeptide UniProtKB:Q6NV44 (1) 559 aa
    Select Tool
    Sequence Information (all 26)
    ORTHOLOGY for fzd7a ( Chr: 9 )
    CITATIONS (61)