ZFIN ID: ZDB-GENE-990415-213
Gene Name: peroxisome proliferator-activated receptor gamma
Gene Symbol: pparg    Nomenclature History

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Previous Names: PPAR[g], ARF6 (1), NR1C3 (1), nr1c3 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 11 Mapping Details/Browsers
Description: Predicted to have several functions, including DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II repressing transcription factor binding activity; and nuclear receptor transcription coactivator activity. Involved in triglyceride homeostasis. Predicted to localize to the RNA polymerase II transcription factor complex. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); end stage renal failure; familial combined hyperlipidemia; lipodystrophy (multiple); and obesity. Is expressed in several structures, including adipose tissue; digestive system; female organism; male organism; and pleuroperitoneal region. Orthologous to human PPARG (peroxisome proliferator activated receptor gamma).
Genome Resources: Alliance (1),  Gene:557037 (1),  Ensembl(GRCz11):ENSDARG00000031848 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa1220 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa1737 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa27703 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa34999 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35000 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • wi701 Indel Unknown Unknown TALEN
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-pparg N/A 1
    MO2-pparg N/A 1
    TALEN1-pparg 1
    PHENOTYPE
    Data: 5 figures from 2 publications
    Observed in:
    DISEASE ASSOCIATED WITH pparg HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    familial partial lipodystrophy type 3 Alliance Insulin resistance, severe, digenic 604367
    Lipodystrophy, familial partial, type 3 604367
    obesity Alliance Obesity, severe 601665
    type 2 diabetes mellitus Alliance {Diabetes, type 2} 125853
    Carotid intimal medial thickness 1 609338
    [Obesity, resistance to]
    DISEASE ASSOCIATED WITH pparg VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process triglyceride homeostasis (more)
    Cellular Component cytoplasm (more)
    Molecular Function DNA binding (more)
    GO Terms (all 38)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000536 Nuclear hormone receptor, ligand-binding domain
    Domain IPR001628 Zinc finger, nuclear hormone receptor-type
    Family IPR001723 Nuclear hormone receptor
    Family IPR003074 Peroxisome proliferator-activated receptor
    Family IPR003077 Peroxisome proliferator-activated receptor gamma
    Homologous_superfamily IPR013088 Zinc finger, NHR/GATA-type
    Domain IPR022590 Peroxisome proliferator-activated receptor gamma, N-terminal
    Homologous_superfamily IPR035500 Nuclear hormone receptor-like domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA pparg-201 (1)    Ensembl 1359
    pparg-202 (1)    Ensembl 535
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM pparg No data available
    MARKER RELATIONSHIPS
    pparg Encodes: [EST] dq017619 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131467 (1) 1994 bp
    Genomic GenBank:CABZ01069316 (1) 11761 bp
    Polypeptide UniProtKB:A6XMH6 (1) 527 aa
    Sequence Information (all 31)
    ORTHOLOGY for pparg ( Chr: 11 )
    CITATIONS (132)