Gene

pparg

ID

ZDB-GENE-990415-213

Name

peroxisome proliferator-activated receptor gamma

Symbol

pparg Nomenclature History

Previous Names

PPAR[g]
ARF6 (1)
NR1C3 (1)
nr1c3 (1)

Type

protein_coding_gene

Location

Chr: 11 Mapping Details/Browsers

Description

Predicted to contribute to vitamin D response element binding activity. Involved in triglyceride homeostasis. Predicted to localize to cytoplasm and nucleus. Is expressed in several structures, including adipose tissue; digestive system; female organism; male organism; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in several diseases, including cardiovascular system disease (multiple); end stage renal disease; lipodystrophy (multiple); obesity; and type 2 diabetes mellitus. Orthologous to human PPARG (peroxisome proliferator activated receptor gamma).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

64 figures from 53 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

dq017619 (7 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 9 figures from 4 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With pparg Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Carotid intimal medial thickness 1	609338
		Insulin resistance, severe, digenic	604367
		Lipodystrophy, familial partial, type 3	604367
		Obesity, severe	601665
		[Obesity, resistance to]
		{Diabetes, type 2}	125853

Associated With pparg Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000536	Nuclear hormone receptor, ligand-binding domain
Domain	IPR001628	Zinc finger, nuclear hormone receptor-type
Domain	IPR022590	Peroxisome proliferator-activated receptor gamma, N-terminal
Family	IPR001723	Nuclear hormone receptor
Family	IPR003074	Peroxisome proliferator-activated receptor
Family	IPR003077	Peroxisome proliferator-activated receptor gamma
Homologous_superfamily	IPR013088	Zinc finger, NHR/GATA-type
Homologous_superfamily	IPR035500	Nuclear hormone receptor-like domain superfamily

Domain Details Per Protein

Protein	Length	Nuclear hormone receptor	Nuclear hormone receptor, ligand-binding domain	Nuclear hormone receptor-like domain superfamily	Peroxisome proliferator-activated receptor	Peroxisome proliferator-activated receptor gamma	Peroxisome proliferator-activated receptor gamma, N-terminal	Zinc finger, NHR/GATA-type	Zinc finger, nuclear hormone receptor-type
UniProtKB:A6XMH6 InterPro	527

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	pparg-201 (1) Ensembl	Havana	1359 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
mRNA	pparg-202 (1) Ensembl	Havana	535 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

SignaFish

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations