Gene

vsx1

ID

ZDB-GENE-990415-205

Name

visual system homeobox 1 homolog, chx10-like

Symbol

vsx1 Nomenclature History

Previous Names

etID309864.17 (1)

Type

protein_coding_gene

Location

Chr: 17 Mapping Details/Browsers

Description

Exhibits chromatin binding activity and transcription regulatory region DNA binding activity. Involved in several processes, including negative regulation of axial mesodermal cell fate specification; nervous system development; and paraxial mesodermal cell fate specification. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in corneal dystrophy; keratoconus; and posterior polymorphous corneal dystrophy 1. Is expressed in blastomere; immature eye; nervous system; and neural tube. Orthologous to human VSX1 (visual system homeobox 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

38 figures from 20 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

MGC:73233 (8 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 7 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With vsx1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
keratoconus	Alliance	Keratoconus 1	148300
		?Craniofacial anomalies and anterior segment dysgenesis syndrome	614195

Associated With vsx1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017970	Homeobox, conserved site
Domain	IPR001356	Homeobox domain
Domain	IPR023339	CVC domain
Homologous_superfamily	IPR009057	Homeobox-like domain superfamily