ZFIN ID: ZDB-GENE-990415-205
Gene Name: visual system homeobox 1 homolog, chx10-like
Gene Symbol: vsx1    Nomenclature History

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Previous Name: etID309864.17 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Exhibits chromatin binding activity and transcription regulatory region DNA binding activity. Involved in several processes, including negative regulation of axial mesodermal cell fate specification; nervous system development; and paraxial mesodermal cell fate specification. Predicted to localize to the nucleus. Human ortholog(s) of this gene implicated in corneal dystrophy; keratoconus; and posterior polymorphous corneal dystrophy 1. Is expressed in blastomere; immature eye; nervous system; and neural tube. Orthologous to human VSX1 (visual system homeobox 1).
Genome Resources: Alliance (1),  Gene:30598 (1),  Ensembl(GRCz11):ENSDARG00000056292 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa101 Point Mutation Unknown Unknown ENU
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-vsx1 N/A 3
MO2-vsx1 N/A 2
MO4-vsx1 N/A 3
DISEASE ASSOCIATED WITH vsx1 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
keratoconus Alliance Keratoconus 1 148300
?Craniofacial anomalies and anterior segment dysgenesis syndrome 614195
DISEASE ASSOCIATED WITH vsx1 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process negative regulation of transcription, DNA-templated (more)
Cellular Component nucleus (more)
Molecular Function chromatin binding (more)
GO Terms (all 16)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Domain IPR001356 Homeobox domain
Homologous_superfamily IPR009057 Homeobox-like domain superfamily
Conserved_site IPR017970 Homeobox, conserved site
Domain IPR023339 CVC domain
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA vsx1-202 (1)    Ensembl 1582
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES
Name Type Isotype Host Organism Assay Source Publications
Ab1-vsx1 polyclonal Mouse IHC 1
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM vsx1
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(vsx1:Cerulean) vsx1 Cerulean Danio rerio 1 3
Tg(vsx1:GAL4,myl7:EGFP) myl7vsx1 EGFPGAL4 Danio rerio 1 1
TgBAC(vsx1:GFP) vsx1 GFP Danio rerio 1 30
MARKER RELATIONSHIPS
vsx1 Contained in: [BAC] CH211-67N1 (1)
vsx1 Encodes: [cDNA] MGC:73233 (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_131333 (1) 1587 bp
Genomic GenBank:AL929290 (1) 168517 bp
Select Tool
Polypeptide UniProtKB:F1QTW3 (1) 344 aa
Sequence Information (all 15)
ORTHOLOGY for vsx1 ( Chr: 17 )
CITATIONS (63)