Gene

tdgf1

ID
ZDB-GENE-990415-198
Name
teratocarcinoma-derived growth factor 1
Symbol
tdgf1 Nomenclature History
Previous Names
  • cb85 (1)
  • cripto
  • oep
  • one eyed pinhead
  • one-eyed pinhead
  • wu:fe01d04
  • zgc:109829
Type
protein_coding_gene
Location
Chr: 10 Mapping Details/Browsers
Description
Predicted to have activin receptor binding activity and nodal binding activity. Involved in several processes, including animal organ development; embryonic morphogenesis; and regionalization. Localizes to external side of plasma membrane. Is expressed in several structures, including EVL; cardiovascular system; diencephalon; ectoderm; and mesoderm. Used to study neural tube defect. Human ortholog(s) of this gene implicated in colon cancer; congenital heart disease; and visceral heterotaxy. Orthologous to several human genes including TDGF1 (teratocarcinoma-derived growth factor 1).
Genome Resources
Note
None
Expression
All Expression Data
27 figures from 19 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
64 figures from 42 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tdgf1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Forebrain defects
Associated With tdgf1 Via Experimental Models
Human Disease Fish Conditions Citations
neural tube defect tdgf1m134/m134 standard conditions Ma et al., 2015
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000742 EGF-like domain
Domain IPR019011 Cryptic/Cripto, CFC domain
Domain Details Per Protein
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations