Gene

nkx2.7

ID
ZDB-GENE-990415-179
Name
NK2 transcription factor related 7
Symbol
nkx2.7 Nomenclature History
Previous Names
  • nk2.7
  • nkx2-7
  • zgc:100762
Type
protein_coding_gene
Location
Chr: 8 Mapping Details/Browsers
Description
Predicted to have DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in heart development and regulation of cardiac chamber formation. Predicted to localize to nucleus. Is expressed in heart primordium and lateral plate mesoderm. Orthologous to human NKX2-6 (NK2 homeobox 6).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
10 figures from 8 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
15 figures from 4 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With nkx2.7 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Conotruncal heart malformations 217095
Persistent truncus arteriosus 217095
Associated With nkx2.7 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR017970 Homeobox, conserved site
Domain Details Per Protein
Protein Length Homeobox, conserved site
UniProtKB:Q98873 269
Transcripts
Genome Browsers
Type Name Annotation Method Length (nt) Analysis
mRNA nkx2.7-201 (1) Havana 1176 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations