header logo image header logo text
Downloads Login
Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-990415-166
Gene Name: NRAS proto-oncogene, GTPase
Gene Symbol: nras    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: etID18709.8 (1), fj99a10, wu:fj99a10 (1), zgc:100761, zras-b1 (1)

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 8 Mapping Details/Browsers
Description: Predicted to have GDP binding activity; GTP binding activity; and GTPase activity. Predicted to be involved in Ras protein signal transduction. Predicted to localize to the plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome 6; autoimmune lymphoproliferative syndrome type 4; endocrine gland cancer (multiple); epidermal nevus; and hematologic cancer (multiple). Is expressed in brain; heart; liver; pleuroperitoneal region; and trunk musculature. Orthologous to human NRAS (NRAS proto-oncogene, GTPase).
Genome Resources: Alliance (1),  Gene:30380 (1),  Ensembl(GRCz11):ENSDARG00000038225 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH nras HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
autoimmune lymphoproliferative syndrome type 4 Alliance ?RAS-associated autoimmune lymphoproliferative syndrome type IV, somatic 614470
colorectal cancer Alliance Colorectal cancer, somatic 114500
epidermal nevus Alliance Epidermal nevus, somatic 162900
large congenital melanocytic nevus Alliance Melanocytic nevus syndrome, congenital, somatic 137550
linear nevus sebaceous syndrome Alliance Schimmelpenning-Feuerstein-Mims syndrome, somatic mosaic 163200
Noonan syndrome 6 Alliance Noonan syndrome 6 613224
thyroid gland follicular carcinoma Alliance Thyroid carcinoma, follicular, somatic 188470
Neurocutaneous melanosis, somatic 249400
DISEASE ASSOCIATED WITH nras VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process Ras protein signal transduction (more)
Cellular Component Golgi apparatus (more)
Molecular Function GTPase activity (more)
GO Terms (all 10)
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA nras-201 (1)    Ensembl 2636
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM nras No data available
MARKER RELATIONSHIPS
nras Contained in: [BAC] CH73-77L8 (1) (order this), DKEYP-31A2 (1)
nras Encodes: [EST] fj99a10 (1)
[cDNA] MGC:100761 (1) (order this)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_131145 (1) 2638 bp
Genomic GenBank:CT027601 (1) 81048 bp
Select Tool
Polypeptide UniProtKB:P79737 (1) 188 aa
Sequence Clusters UniGene:233 (1)
Sequence Information (all 16)
ORTHOLOGY for nras ( Chr: 8 )
CITATIONS (38)