Gene

mdm2

ID
ZDB-GENE-990415-153
Name
MDM2 proto-oncogene
Symbol
mdm2 Nomenclature History
Previous Names
  • etID309863.4 (1)
  • sb:eu923
  • zgc:109834
Type
protein_coding_gene
Location
Chr: 4 Mapping Details/Browsers
Description
Predicted to have metal ion binding activity and transferase activity. Involved in several processes, including negative regulation of apoptotic process; negative regulation of cell cycle arrest; and pronephric glomerulus morphogenesis. Predicted to localize to cytoplasm; nucleolus; and nucleoplasm. Human ortholog(s) of this gene implicated in chronic myeloid leukemia; endocrine gland cancer (multiple); glioblastoma multiforme; ichthyosis; and sarcoma. Is expressed in several structures, including blood; intestine; mesoderm; peripheral olfactory organ; and yolk syncytial layer. Orthologous to human MDM2 (MDM2 proto-oncogene).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
80 figures from 62 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
13 figures from 7 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mdm2 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
?Lessel-Kubisch syndrome 618681
{Accelerated tumor formation, susceptibility to} 614401
Associated With mdm2 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001841 Zinc finger, RING-type
Domain IPR001876 Zinc finger, RanBP2-type
Domain IPR003121 SWIB/MDM2 domain
Domain IPR044080 MDM2, modified RING finger, HC subclass
Family IPR016495 p53 negative regulator Mdm2/Mdm4
Family IPR028340 E3 ubiquitin-protein ligase Mdm2
Homologous_superfamily IPR013083 Zinc finger, RING/FYVE/PHD-type
Homologous_superfamily IPR036443 Zinc finger, RanBP2-type superfamily
Homologous_superfamily IPR036885 SWIB/MDM2 domain superfamily
Domain Details Per Protein
Protein Length E3 ubiquitin-protein ligase Mdm2 MDM2, modified RING finger, HC subclass p53 negative regulator Mdm2/Mdm4 SWIB/MDM2 domain SWIB/MDM2 domain superfamily Zinc finger, RanBP2-type Zinc finger, RanBP2-type superfamily Zinc finger, RING/FYVE/PHD-type Zinc finger, RING-type
UniProtKB:O42354 445
UniProtKB:A0A8M2BC69 486
UniProtKB:Q561Z0 475
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-mdm2 polyclonal IgG Rabbit
  • IHC
AnaSpec
4
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations