ZFIN ID: ZDB-GENE-990415-139
Gene Name: lipoprotein lipase
Gene Symbol: lpl    Nomenclature History

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Previous Names: fb62e04, fc49b03, wu:fb62e04 (1), wu:fc49b03 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 22 Mapping Details/Browsers
Description: Predicted to have apolipoprotein binding activity; lipoprotein lipase activity; and phospholipase activity. Involved in definitive hemopoiesis and response to (R)-carnitine. Predicted to localize to the extracellular space. Human ortholog(s) of this gene implicated in Alzheimer's disease; artery disease (multiple); familial hyperlipidemia (multiple); muscular disease; and type 2 diabetes mellitus. Is expressed in several structures, including cardiovascular system; head; immature eye; midbrain; and pleuroperitoneal region. Orthologous to human LPL (lipoprotein lipase).
Genome Resources: Alliance (1),  Gene:30354 (1),  Ensembl(GRCz11):ENSDARG00000087697 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa24119 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sd51 Indel Exon 4 Frameshift, Premature Stop CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-lpl 2
    MO1-lpl N/A 1
    DISEASE ASSOCIATED WITH lpl HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    familial combined hyperlipidemia Alliance Combined hyperlipidemia, familial 144250
    familial lipoprotein lipase deficiency Alliance Lipoprotein lipase deficiency 238600
    [High density lipoprotein cholesterol level QTL 11] 238600
    DISEASE ASSOCIATED WITH lpl VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process definitive hemopoiesis (more)
    Cellular Component chylomicron (more)
    Molecular Function carboxylic ester hydrolase activity (more)
    GO Terms (all 18)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR000734 Triacylglycerol lipase family
    Domain IPR001024 PLAT/LH2 domain
    Family IPR002330 Lipoprotein lipase
    Domain IPR013818 Lipase/vitellogenin
    Family IPR016272 Lipase, LIPH-type
    Homologous_superfamily IPR029058 Alpha/Beta hydrolase fold
    Domain IPR033906 Lipase, N-terminal
    Homologous_superfamily IPR036392 PLAT/LH2 domain superfamily
    TRANSCRIPTS No data available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM lpl No data available
    MARKER RELATIONSHIPS
    lpl Encodes: [EST] fb62e04 (1), fc49b03 (1), IMAGE:7152644 (1)
    [cDNA] MGC:77678 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131127 (1) 1904 bp
    Genomic GenBank:U57657 348 bp
    Polypeptide UniProtKB:F1QHK8 (1) 511 aa
    Sequence Information (all 21)
    ORTHOLOGY for lpl ( Chr: 22 )
    CITATIONS (72)