ZFIN ID: ZDB-GENE-990415-127
Gene Name: SIX homeobox 3a
Gene Symbol: six3a    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: six3.1, six3 (1), etID309945.13 (1), etID46760.13 (1), wu:fa01b08, wu:fc10a08 (1)

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and transcription regulatory region sequence-specific DNA binding activity. Involved in brain development and optic nerve morphogenesis. Predicted to localize to the nucleus and transcription factor complex. Human ortholog(s) of this gene implicated in holoprosencephaly and holoprosencephaly 2. Is expressed in several structures, including anterior neural keel; nervous system; neural plate; optic vesicle; and presumptive telencephalon. Orthologous to human SIX3 (SIX homeobox 3).
Genome Resources: Alliance (1),  Gene:30635 (1),  Ensembl(GRCz11):ENSDARG00000058008 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa42147 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • vu129 Point Mutation Unknown Missense ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-six3a N/A 1
    MO1-six3a,six3b N/A 4
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH six3a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    holoprosencephaly 2 Alliance Holoprosencephaly 2 157170
    Schizencephaly 269160
    DISEASE ASSOCIATED WITH six3a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process optic nerve development (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR001356 Homeobox domain
    Domain IPR031701 Homeobox protein SIX1, N-terminal SD domain
    Family IPR032949 Homeobox protein SIX3
    Homologous_superfamily IPR009057 Homeobox-like domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA six3a-201 (1)    Ensembl 1889
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM six3a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-3.6six3a:EGFP) six3a EGFP Danio rerio 1 3
    MARKER RELATIONSHIPS
    six3a Contained in: [BAC] DKEY-103L3 (1) (order this)
    six3a Encodes: [EST] fc10a08 (1)
    [cDNA] MGC:73025 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131362 (1) 1914 nt
    Genomic GenBank:BX537274 (1) 151298 nt
    Select Tool
    Polypeptide UniProtKB:O73708 (1) 294 aa
    Sequence Information (all 14)
    ORTHOLOGY for six3a ( Chr: 13 )
    CITATIONS (94)