ZFIN ID: ZDB-GENE-980605-30
Gene Name: transcription factor 7 like 1a
Gene Symbol: tcf7l1a    Nomenclature History

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Previous Names: hdl, tcf-3 (1), tcf3 (1), tcf3a (1), headless, HMG-box transcription factor

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Exhibits DNA binding activity. Involved in several processes, including cell proliferation in dorsal spinal cord; negative regulation of Wnt signaling pathway; and nervous system development. Localizes to nucleus. Is expressed in several structures, including axis; digestive system; midbrain neural keel; nervous system; and posterior neural tube. Orthologous to human TCF7L1 (transcription factor 7 like 1).
Genome Resources: Alliance (1),  Gene:30523 (1),  Ensembl(GRCz11):ENSDARG00000038159 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la011723Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la011897Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • m881 Point Mutation Unknown Splicing Variant, Frameshift, Premature Stop
    sa384 Point Mutation Unknown Premature Stop ENU
    sa44731 Point Mutation Unknown Unknown ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-tcf7l1a N/A 15
    MO2-tcf7l1a N/A 4
    MO3-tcf7l1a N/A 1
    MO4-tcf7l1a N/A 1
    DISEASE ASSOCIATED WITH tcf7l1a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH tcf7l1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process cell proliferation in dorsal spinal cord (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 30)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA tcf7l1a-203 (1)    Ensembl 1803
    ncRNA tcf7l1a-002 (1)    Ensembl 708
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tcf7l1a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    tg(hsp70l:loxp-stop-loxp-mcherry-dntcf7l1a) hsp70l LOXPmCherrytcf7l1a Danio rerio 1 1
    Tg(hsp70l:tcf7l1a-GFP) hsp70l GFPtcf7l1a Danio rerio 1 52
    Tg(UAS:dntcf7l1a-2A-mKate2,myl7:EGFP) myl7UAS 2AEGFPmKate2tcf7l1a Danio rerio 1 1
    Tg(UAS:tcf7l1a-EGFP) UAS EGFPtcf7l1a Danio rerio 1 3
    MARKER RELATIONSHIPS
    tcf7l1a Contained in: [BAC] CH73-339I22 (1)
    tcf7l1a Encodes: [cDNA] MGC:63891 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131269 (1) 2717 nt
    Genomic GenBank:CU467905 (1) 76749 nt
    Select Tool
    Polypeptide UniProtKB:Q9YHE8 (1) 560 aa
    Sequence Information (all 13)
    ORTHOLOGY for tcf7l1a ( Chr: 10 )
    CITATIONS (120)