ZFIN ID: ZDB-GENE-980526-492
Gene Name: muscle segment homeobox 2b
Gene Symbol: msx2b    Nomenclature History

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Previous Names: msh-D, mshD, msxd (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in embryonic morphogenesis. Predicted to localize to nucleus. Is expressed in several structures, including fin bud; median fin fold; sensory system; solid lens vesicle; and vent. Human ortholog(s) of this gene implicated in several diseases, including cleft lip; orofacial cleft 5; parietal foramina; tooth and nail syndrome; and tooth disease (multiple). Orthologous to several human genes including MSX2 (msh homeobox 2).
Genome Resources: Alliance (1),  Gene:30531 (1),  Ensembl(GRCz11):ENSDARG00000101023 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa935 Point Mutation Unknown Premature Stop ENU
PHENOTYPE No data available
DISEASE ASSOCIATED WITH msx2b HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
craniosynostosis Alliance Craniosynostosis 2 604757
parietal foramina Alliance Parietal foramina 1 168500
Parietal foramina with cleidocranial dysplasia 168550
DISEASE ASSOCIATED WITH msx2b VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process multicellular organism development (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 8)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS No data available
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM msx2b No data available
MARKER RELATIONSHIPS
msx2b Encodes: [EST] eu398 (1)
[cDNA] MGC:123159 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_131276 (1)
Genomic GenBank:CABZ01034738 (1) 12747 nt
Polypeptide UniProtKB:A0A0J9YJK2 (1) 241 aa
Sequence Information (all 19)
ORTHOLOGY for msx2b ( Chr: 21 )
CITATIONS (44)