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Gene

fgfr4

ID
ZDB-GENE-980526-488
Name
fibroblast growth factor receptor 4
Symbol
fgfr4 Nomenclature History
Previous Names
  • etID309818.21 (1)
  • wu:fc13h10 (1)
  • zgc:111935
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Predicted to enable ATP binding activity; fibroblast growth factor binding activity; and fibroblast growth factor-activated receptor activity. Acts upstream of or within regulation of hematopoietic stem cell differentiation. Predicted to be located in endoplasmic reticulum; endosome; and plasma membrane. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Is expressed in several structures, including brain; cardiovascular system; digestive system; head; and head mesenchyme. Orthologous to human FGFR4 (fibroblast growth factor receptor 4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
35 figures from 29 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With fgfr4 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
{Cancer progression/metastasis}
Associated With fgfr4 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008266 Tyrosine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR003598 Immunoglobulin subtype 2
Domain IPR003599 Immunoglobulin subtype
Domain IPR007110 Immunoglobulin-like domain
Domain IPR013098 Immunoglobulin I-set
Domain IPR013151 Immunoglobulin
Domain IPR020635 Tyrosine-protein kinase, catalytic domain
Domain IPR041159 Fibroblast growth factor receptor, transmembrane domain
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR013783 Immunoglobulin-like fold
Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
Domain Details Per Protein
Protein Length Fibroblast growth factor receptor, transmembrane domain Immunoglobulin Immunoglobulin I-set Immunoglobulin-like domain Immunoglobulin-like domain superfamily Immunoglobulin-like fold Immunoglobulin subtype Immunoglobulin subtype 2 Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Serine-threonine/tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase, active site Tyrosine-protein kinase, catalytic domain
UniProtKB:A4JYD8 521
UniProtKB:Q90413 922
UniProtKB:B7ZVT9 922
UniProtKB:A0A2R8QCP1 844
UniProtKB:A0A286Y9G6 923
Transcripts
Genome Browsers
Interactions and Pathways
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations