ZFIN ID: ZDB-GENE-980526-488
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Gene Name: fibroblast growth factor receptor 4
Gene Symbol: fgfr4    Nomenclature History

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Previous Names: etID309818.21 (1), wu:fc13h10 (1), zgc:111935

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have ATP binding activity; fibroblast growth factor binding activity; and fibroblast growth factor-activated receptor activity. Involved in regulation of hematopoietic stem cell differentiation. Predicted to localize to the integral component of plasma membrane and receptor complex. Is expressed in several structures, including brain; cardiovascular system; digestive system; head; and head mesenchyme. Orthologous to human FGFR4 (fibroblast growth factor receptor 4).
Genome Resources: Alliance (1),  Gene:100000160 (1),  Ensembl(GRCz11):ENSDARG00000069105 (2)
GENE EXPRESSION
All Expression Data: 31 figures from 26 publications
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu3514 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
    • hu3582 Unknown Unknown Unknown ENU
    la022005Tg Transgenic Insertion Unknown Unknown DNA
    sa6682 Point Mutation Unknown Premature Stop ENU
    sa24004 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa24005 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • sa37357 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
    • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-fgfr4
    		1
    CRISPR2-fgfr4
    		1
    MO1-fgfr4 N/A 2
    MO2-fgfr4 N/A 2
    MO3-fgfr4 N/A 1
    PHENOTYPE
    Data: 3 figures from 3 publications
    Observed in:
    DISEASE ASSOCIATED WITH fgfr4 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    {Cancer progression/metastasis}
    DISEASE ASSOCIATED WITH fgfr4 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process regulation of hematopoietic stem cell differentiation (more)
    Cellular Component endoplasmic reticulum (more)
    Molecular Function protein binding (more)
    GO Terms (all 24)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000719 Protein kinase domain
    Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
    Domain IPR003598 Immunoglobulin subtype 2
    Domain IPR003599 Immunoglobulin subtype
    Domain IPR007110 Immunoglobulin-like domain
    Active_site IPR008266 Tyrosine-protein kinase, active site
    Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
    Domain IPR013098 Immunoglobulin I-set
    Domain IPR013151 Immunoglobulin
    Homologous_superfamily IPR013783 Immunoglobulin-like fold
    Family IPR016248 Fibroblast growth factor receptor family
    Binding_site IPR017441 Protein kinase, ATP binding site
    Domain IPR020635 Tyrosine-protein kinase, catalytic domain
    Homologous_superfamily IPR036179 Immunoglobulin-like domain superfamily
    Domain IPR041159 Fibroblast growth factor receptor, transmembrane domain
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA fgfr4-201 (1)    Ensembl 5011
    Select Tool
    Browsers: UCSC,  NCBI,  Ensembl,  ZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM fgfr4 No data available
    MARKER RELATIONSHIPS
    fgfr4 Contained in: [BAC] CH211-281E1 (1), DKEY-53B2 (1) (order this)
    fgfr4 Contains: [BAC END] zc120k11.ya (1)
    fgfr4 Encodes: [EST] fc13h10 (1)
    [cDNA] cssl:d109 (1), MGC:198431 (1)
    fgfr4 Has Artifact: [cDNA] MGC:111935
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131430 (1) 4705 bp
    Select Tool
    Genomic GenBank:BX649250 (1) 165729 bp
    Select Tool
    Polypeptide UniProtKB:A0A286Y9G6 (1) 923 aa
    Select Tool
    Sequence Information (all 24)
    ORTHOLOGY for fgfr4 ( Chr: 21 )
    CITATIONS (93)