Gene

fgfr4

ID

ZDB-GENE-980526-488

Name

fibroblast growth factor receptor 4

Symbol

fgfr4 Nomenclature History

Previous Names

etID309818.21 (1)
wu:fc13h10 (1)
zgc:111935

Type

protein_coding_gene

Location

Chr: 21 Mapping Details/Browsers

Description

Predicted to enable ATP binding activity; fibroblast growth factor binding activity; and fibroblast growth factor-activated receptor activity. Acts upstream of or within regulation of hematopoietic stem cell differentiation. Predicted to be located in endoplasmic reticulum; endosome; and plasma membrane. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Predicted to be integral component of plasma membrane. Is expressed in several structures, including brain; cardiovascular system; digestive system; head; and head mesenchyme. Orthologous to human FGFR4 (fibroblast growth factor receptor 4).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

35 figures from 29 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UCSC scRNA-seq

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 3 figures from 3 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With fgfr4 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		{Cancer progression/metastasis}

Associated With fgfr4 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR008266	Tyrosine-protein kinase, active site
Binding_site	IPR017441	Protein kinase, ATP binding site
Domain	IPR000719	Protein kinase domain
Domain	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain	IPR003598	Immunoglobulin subtype 2
Domain	IPR003599	Immunoglobulin subtype
Domain	IPR007110	Immunoglobulin-like domain
Domain	IPR013098	Immunoglobulin I-set
Domain	IPR013151	Immunoglobulin
Domain	IPR020635	Tyrosine-protein kinase, catalytic domain
Domain	IPR041159	Fibroblast growth factor receptor, transmembrane domain
Homologous_superfamily	IPR011009	Protein kinase-like domain superfamily
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR036179	Immunoglobulin-like domain superfamily

Domain Details Per Protein

Protein	Length	Fibroblast growth factor receptor, transmembrane domain	Immunoglobulin	Immunoglobulin I-set	Immunoglobulin-like domain	Immunoglobulin-like domain superfamily	Immunoglobulin-like fold	Immunoglobulin subtype	Immunoglobulin subtype 2	Protein kinase, ATP binding site	Protein kinase domain	Protein kinase-like domain superfamily	Serine-threonine/tyrosine-protein kinase, catalytic domain	Tyrosine-protein kinase, active site	Tyrosine-protein kinase, catalytic domain
UniProtKB:A4JYD8 InterPro	521
UniProtKB:Q90413 InterPro	922
UniProtKB:B7ZVT9 InterPro	922
UniProtKB:A0A2R8QCP1 InterPro	844
UniProtKB:A0A286Y9G6 InterPro	923