ZFIN ID: ZDB-GENE-980526-488 |
Gene Name: | fibroblast growth factor receptor 4 | ||||||
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Gene Symbol: | fgfr4 Nomenclature History | ||||||
Previous Names: | etID309818.21 (1), wu:fc13h10 (1), zgc:111935 | ||||||
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Gene Type: | protein_coding_gene | ||||||
Location: | Chr: 21 Mapping Details/Browsers | ||||||
Description: | Predicted to have ATP binding activity; fibroblast growth factor binding activity; and fibroblast growth factor-activated receptor activity. Involved in regulation of hematopoietic stem cell differentiation. Predicted to localize to the integral component of plasma membrane and receptor complex. Is expressed in several structures, including brain; cardiovascular system; digestive system; head; and head mesenchyme. Orthologous to human FGFR4 (fibroblast growth factor receptor 4). | ||||||
Genome Resources: | Alliance (1), Gene:100000160 (1), Ensembl(GRCz11):ENSDARG00000069105 (2) |
All Expression Data: | 31 figures from 26 publications |
Wild-type Stages, Structures: | Gastrula:50%-epiboly (5.25h-5.66h) to Adult (90d-730d, breeding adult) |
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Curated Microarray Expression: | GEO (1) |
Allele | Type | Localization | Consequence | Mutagen | Suppliers |
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hu3514 | Point Mutation | Unknown | Premature Stop | ENU |
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hu3582 | Unknown | Unknown | Unknown | ENU | |
la022005Tg | Transgenic Insertion | Unknown | Unknown | DNA | |
sa6682 | Point Mutation | Unknown | Premature Stop | ENU | |
sa24004 | Point Mutation | Unknown | Splice Site | ENU |
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sa24005 | Point Mutation | Unknown | Premature Stop | ENU |
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sa37357 | Point Mutation | Unknown | Premature Stop | ENU |
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Targeting Reagent | Created Alleles | Publications |
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CRISPR1-fgfr4 |
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1 |
CRISPR2-fgfr4 |
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1 |
MO1-fgfr4 | N/A | 2 |
MO2-fgfr4 | N/A | 2 |
MO3-fgfr4 | N/A | 1 |
Data: | 3 figures from 3 publications |
Observed in: |
Ontology | GO Term |
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Biological Process | regulation of hematopoietic stem cell differentiation (more) |
Cellular Component | endoplasmic reticulum (more) |
Molecular Function | protein binding (more) |
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Type | Name | Length (nt) | Analysis | |
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mRNA |
fgfr4-201
(1)
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5011 |
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Browsers: UCSC, NCBI, Ensembl, ZFIN |
fgfr4 Contained in: | [BAC] CH211-281E1 (1) (order this), DKEY-53B2 (1) (order this) |
fgfr4 Contains: | [BAC END] zc120k11.ya (1) |
fgfr4 Encodes: |
[EST]
fc13h10 (1)
[cDNA] cssl:d109 (1), MGC:198431 (1) (order this) |
fgfr4 Has Artifact: | [cDNA] MGC:111935 (order this) |
Type | Accession # | Length (bp/aa) | Analysis |
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RNA | RefSeq:NM_131430 (1) | 4705 bp |
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Genomic | GenBank:BX649250 (1) | 165729 bp | |
Polypeptide | UniProtKB:A0A286Y9G6 (1) | 923 aa |
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Sequence Clusters | UniGene:75058 (1) |