ZFIN Gene: fgfr4

ZFIN ID: ZDB-GENE-980526-488

ZFIN ID: ZDB-GENE-980526-488

Gene Name:

fibroblast growth factor receptor 4

Gene Symbol:

fgfr4 Nomenclature History

Previous Names:

etID309818.21 (1), wu:fc13h10 (1), zgc:111935

Gene Type:

protein_coding_gene

Location:

Chr: 21 Mapping Details/Browsers

Description:

Predicted to have ATP binding activity; fibroblast growth factor binding activity; and fibroblast growth factor-activated receptor activity. Involved in regulation of hematopoietic stem cell differentiation. Predicted to localize to the integral component of plasma membrane and receptor complex. Is expressed in several structures, including brain; cardiovascular system; digestive system; head; and head mesenchyme. Orthologous to human FGFR4 (fibroblast growth factor receptor 4).

Genome Resources:

Alliance (1), Gene:100000160 (1), Ensembl(GRCz11):ENSDARG00000069105 (2)

GENE EXPRESSION
All Expression Data:	31 figures from 26 publications
Wild-type Stages, Structures:	Gastrula:50%-epiboly (5.25h-5.66h) to Adult (90d-730d, breeding adult)
	brain caudal vein plexus cephalic musculature choroidal fissure cranial ganglion diencephalon eye fin bud forebrain ventricular zone forebrain habenula head head mesenchyme heart hindbrain dorsal region hindbrain intestinal epithelium lens anatomical region lens mandibular arch skeleton maxillary barbel midbrain dorsal region midbrain otic vesicle periocular mesenchyme pharynx pineal complex presumptive neural retina retina rhombomere 1 segmental plate solid lens vesicle somite tectal ventricle proliferative region telencephalon thalamus unspecified ventral telencephalon whole organism
Curated Microarray Expression:	GEO (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
hu3514	Point Mutation	Unknown	Premature Stop	ENU	Zebrafish International Resource Center (ZIRC) (order this)
hu3582	Unknown	Unknown	Unknown	ENU
la022005Tg	Transgenic Insertion	Unknown	Unknown	DNA
sa6682	Point Mutation	Unknown	Premature Stop	ENU
sa24004	Point Mutation	Unknown	Splice Site	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa24005	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)
sa37357	Point Mutation	Unknown	Premature Stop	ENU	European Zebrafish Resource Center (EZRC) (order this) Zebrafish International Resource Center (ZIRC) (order this)

Sequence Targeting Reagents

Targeting Reagent	Created Alleles	Publications
CRISPR1-fgfr4		1
CRISPR2-fgfr4		1
MO1-fgfr4	N/A	2
MO2-fgfr4	N/A	2
MO3-fgfr4	N/A	1

PHENOTYPE

Data:	3 figures from 3 publications
Observed in:	heart hindbrain optic cup solid lens vesicle somite ventral wall of dorsal aorta whole organism

DISEASE ASSOCIATED WITH fgfr4 HUMAN ORTHOLOG

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		{Cancer progression/metastasis}

DISEASE ASSOCIATED WITH fgfr4 VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	regulation of hematopoietic stem cell differentiation (more)
Cellular Component	endoplasmic reticulum (more)
Molecular Function	protein binding (more)

GO Terms (all 24)

PROTEIN FAMILIES, DOMAINS AND SITES
InterPro:IPR000719 (1) InterPro:IPR001245 (1) InterPro:IPR003598 (1) InterPro:IPR003599 (1) InterPro:IPR007110 (1) InterPro:IPR008266 (1) InterPro:IPR011009 (1) InterPro:IPR013098 (1) InterPro:IPR013151 (1) InterPro:IPR013783 (1) InterPro:IPR016248 (1) InterPro:IPR017441 (1) InterPro:IPR020635 (1) InterPro:IPR036179 (1) InterPro:IPR041159 (1)	PROSITE:PS00107 (1) PROSITE:PS00109 (1) PROSITE:PS50011 (1) PROSITE:PS50835 (1)	Pfam:PF00047 (1) Pfam:PF07679 (1) Pfam:PF07714 (1) Pfam:PF18123 (1)	EC:2.7.10.1 (1)

TRANSCRIPTS
Type	Name	Length (nt)	Analysis
mRNA	fgfr4-201 (1)	5011	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Browsers: UCSC, NCBI, Ensembl, ZFIN

INTERACTIONS AND PATHWAYS

SignaFish

ANTIBODIES No data available

PLASMIDS No data available

CONSTRUCTS WITH SEQUENCES FROM fgfr4 No data available

MARKER RELATIONSHIPS

fgfr4 Contained in:	[BAC] CH211-281E1 (1) (order this), DKEY-53B2 (1) (order this)
fgfr4 Contains:	[BAC END] zc120k11.ya (1)
fgfr4 Encodes:	[EST] fc13h10 (1) [cDNA] cssl:d109 (1), MGC:198431 (1) (order this)
fgfr4 Has Artifact:	[cDNA] MGC:111935 (order this)

SEQUENCE INFORMATION

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_131430 (1)	4705 bp	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:BX649250 (1)	165729 bp	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:A0A286Y9G6 (1)	923 aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast
Sequence Clusters	UniGene:75058 (1)

Sequence Information (all 25)

ORTHOLOGY for fgfr4 ( Chr: 21 )

CITATIONS (92)

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