ZFIN ID: ZDB-GENE-980526-474
Gene Name: bone morphogenetic protein 2b
Gene Symbol: bmp2b    Nomenclature History

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Previous Names: bmp2-4, zbmp-2, zbmp2, cb670 (1), etID309839.20 (1), swirl, swr

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 20 Mapping Details/Browsers
Description: Exhibits protein heterodimerization activity and protein homodimerization activity. Involved in several processes, including animal organ development; determination of bilateral symmetry; and gastrulation. Predicted to localize to the extracellular space. Human ortholog(s) of this gene implicated in bone disease (multiple); hemochromatosis type 1; otosclerosis; prostate cancer; and tooth agenesis. Is expressed in several structures, including digestive system; ectoderm; fin; head; and mesoderm. Orthologous to human BMP2 (bone morphogenetic protein 2).
Genome Resources: Alliance (1),  Gene:30632 (1),  Ensembl(GRCz11):ENSDARG00000041430 (1)
GENE EXPRESSION
All Expression Data: 153 figures from 115 publications
Directly Submitted Expression Data: 6 figures (47 images) from Thisse et al., 2001 [cb670]
Wild-type Stages, Structures: Blastula:1k-cell (3.0h-3.33h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
bmp2b_unspecified Unspecified Unknown Unknown
sa18243 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • ta72a Point Mutation Unknown Stop Loss ENU
  • China Zebrafish Resource Center (CZRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tc300a Point Mutation Unknown Missense ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tdc24 Point Mutation Unknown Premature Stop
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-bmp2b N/A 11
    MO2-bmp2b N/A 13
    MO3-bmp2b N/A 1
    MO4-bmp2b N/A 1
    MO5-bmp2b N/A 1
    DISEASE ASSOCIATED WITH bmp2b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    brachydactyly type A2 Alliance Brachydactyly, type A2 112600
    hemochromatosis type 1 Alliance {HFE hemochromatosis, modifier of} 235200
    Short stature, facial dysmorphism, and skeletal anomalies with or without cardiac anomalies 617877
    DISEASE ASSOCIATED WITH bmp2b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process determination of ventral identity (more)
    Cellular Component extracellular region (more)
    Molecular Function identical protein binding (more)
    GO Terms (all 30)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR001111 TGF-beta, propeptide
    Domain IPR001839 Transforming growth factor-beta, C-terminal
    Family IPR015615 Transforming growth factor-beta-related
    Conserved_site IPR017948 Transforming growth factor beta, conserved site
    Homologous_superfamily IPR029034 Cystine-knot cytokine
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA bmp2b-201 (1)    Ensembl 1961
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM bmp2b
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-2.27bmp2b:bmp2b-EGFP) bmp2b bmp2bEGFP Danio rerio 1 1
    Tg(hsp70l:bmp2b) hsp70l bmp2b Danio rerio 1 41
    Tg(UAS:bmp2b-UTRnanos3) UAS bmp2bnanos3UTR Danio rerio 1 1
    Tg1(hsp70l:bmp2b) hsp70l bmp2b Danio rerio 1 2
    MARKER RELATIONSHIPS
    bmp2b Contained in: [BAC] CH211-213I16 (1)
    bmp2b Encodes: [EST] cb670 (1)
    [cDNA] MGC:92556 (1), MGC:136722 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131360 (1) 1732 bp
    Genomic GenBank:AL929237 (1) 205393 bp Blast at MegaBLAST
    Polypeptide UniProtKB:O13108 (1) 411 aa
    Sequence Clusters UniGene:568 (1)
    Sequence Information (all 24)
    ORTHOLOGY for bmp2b ( Chr: 20 )
    CITATIONS (399)