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ZIRC
ZFIN ID: ZDB-GENE-980526-440
Gene Name: core-binding factor subunit beta
Gene Symbol: cbfb
Sequence Ontology ID : SO:0000704

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Previous Name: unp1266

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(Including Attributions)
Location: Chr: 18 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Exhibits protein heterodimerization activity. Contributes to DNA binding activity and transcription coregulator activity. Involved in several processes, including heart contraction; lymphoid lineage  ...
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hg10 Small Deletion Exon 3 Frameshift, Premature Stop ZINC_FINGER_NUCLEASE
hg11 Insertion Exon 3 Frameshift, Premature Stop ZINC_FINGER_NUCLEASE
la020335Tg Transgenic Insertion Unknown Unknown DNA
sa5910 Point Mutation Unknown Splice Site ENU
w128 Small Deletion Exon 2 Premature Stop TALEN
Targeting reagents:
DISEASE ASSOCIATED WITH cbfb HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
acute myeloid leukemia Myeloid leukemia, acute, M4/M4Eo subtype, somatic 601626
DISEASE ASSOCIATED WITH cbfb VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process heart contraction (more)
Cellular Component nucleus (more)
Molecular Function CONTRIBUTES_TO transcription coregulator activity (more)
GO Terms (all 14)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR003417 (1)
  • InterPro:IPR036552 (1)
  • Pfam:PF02312 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    ncRNA cbfb-005 (1) 545
    cbfb-006 (1) 431
    cbfb-007 (1) 300
    cbfb-011 (1) 261
    mRNA cbfb-201 (1) 2501
    cbfb-202 (1) 783
    cbfb-203 (1) 4078
    cbfb-204 (1) 636
    cbfb-205 (1) 642
    cbfb-206 (1) 587
    cbfb-207 (1) 781
    GENE PRODUCT DESCRIPTION No description available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM cbfb No data available
    MARKER RELATIONSHIPS
    cbfbContained in: [BAC] CH211-212B13 (1) (order this), CH211-262P15 (1) (order this)
    cbfbEncodes: [cDNA] MGC:193675 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_199209 (1) 2731bp
    Genomic GenBank:AL953894 (1) 222376bp Blast at MegaBLAST
    Polypeptide UniProtKB:A0A0B4P4E8 (1) 201aa
    Sequence Clusters UniGene:83043 (1)
    Sequence Information (all 65)
    ORTHOLOGY for cbfb (Chr: 18)
    CITATIONS (40)