ZFIN ID: ZDB-GENE-980526-419
Gene Name: LIM domain only 2 (rhombotin-like 1)
Gene Symbol: lmo2    Nomenclature History

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Previous Names: ttg2 (1), wu:fc83a08, zgc:111930

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 18 Mapping Details/Browsers
Description: Predicted to contribute to DNA binding activity. Involved in several processes, including fin regeneration; hemopoiesis; and retinal blood vessel morphogenesis. Predicted to localize to the nucleus and protein-containing complex. Is expressed in several structures, including angioblastic mesenchymal cell; hematopoietic system; mesoderm; pronephros; and vasculature. Orthologous to human LMO2 (LIM domain only 2).
Genome Resources: Alliance (1),  Gene:30332 (1),  Ensembl(GRCz11):ENSDARG00000095019 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
pku684ld Small Deletion Enhancer Unknown
vu270 Point Mutation Unknown Premature Stop ENU
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-lmo2 N/A 2
MO2-lmo2 N/A 4
DISEASE ASSOCIATED WITH lmo2 HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Leukemia, acute T-cell 180385
DISEASE ASSOCIATED WITH lmo2 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process blood vessel endothelial cell migration (more)
Cellular Component nucleus (more)
Molecular Function CONTRIBUTES_TO   DNA binding (more)
GO Terms (all 13)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Domain IPR001781 Zinc finger, LIM-type
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA lmo2-201 (1)    Ensembl 1805
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
CONSTRUCTS WITH SEQUENCES FROM lmo2
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(lmo2:Cre) lmo2 Cre Danio rerio 1 5
Tg(lmo2:DsRed) lmo2 DsRed Danio rerio 1 18
Tg(lmo2:EGFP) lmo2 EGFP Danio rerio 2 10
Tg(lmo2:LOXP-DsRed-LOXP-bmi1-EGFP) lmo2 bmi1aDsRedEGFP Danio rerio 1 3
Tg(lmo2:LOXP-DsRed-LOXP-EGFP) lmo2 DsRedEGFP Danio rerio 1 7
Tg(lmo2:LOXP-DsRed-LOXP-EGFP-dncebpa) lmo2 cebpaDsRedEGFP Danio rerio 1 3
Tg(lmo2:LOXP-DsRed-LOXP-hoxb4a-EGFP) lmo2 DsRedEGFPhoxb4aLOXP Danio rerio 1 1
Tg(lmo2:mir30e-actb1-DsRed) lmo2 actb1DsRedmir30e-2 Danio rerio 1 2
Tg2(lmo2:LOXP-DsRed-LOXP-EGFP) lmo2 DsRedEGFPLOXP Danio rerio 1 1
MARKER RELATIONSHIPS
lmo2 Contained in: [BAC] CH73-110E4 (1), DKEY-10O6 (1) (order this)
lmo2 Encodes: [EST] fc83a08 (1) (order this)
[cDNA] MGC:111930 (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_131111 (1) 1726 bp
Genomic GenBank:CT025900 (1) 126992 bp
Select Tool
Polypeptide UniProtKB:Q9PTJ3 (1) 159 aa
Sequence Information (all 15)
ORTHOLOGY for lmo2 ( Chr: 18 )
CITATIONS (166)