ZFIN ID: ZDB-GENE-980526-404
Gene Name: forkhead box A2
Gene Symbol: foxa2    Nomenclature History

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Previous Names: ax, axl, axial (1), etID309811.17 (1), fkd1 (1), HNF-3B, hnf3b, ik:tdsubc_2g8, mol, monorail, tdsubc_2g8, wu:fe05g04 (1), xx:tdsubc_2g8

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Exhibits transcription regulatory region sequence-specific DNA binding activity. Involved in axial mesoderm morphogenesis; endoderm development; and nervous system development. Predicted to localize to the nucleus. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Is expressed in several structures, including central nervous system; digestive system; endoderm; mesoderm; and swim bladder. Orthologous to human FOXA2 (forkhead box A2).
Genome Resources: Alliance (1),  Gene:30126 (1),  Ensembl(GRCz11):ENSDARG00000003411 (2)
GENE EXPRESSION
All Expression Data: 145 figures from 114 publications
Wild-type Stages, Structures: Blastula:30%-epiboly (4.66h-5.25h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
st20 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • tv53a Point Mutation Unknown Premature Stop ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-foxa2 N/A 7
    DISEASE ASSOCIATED WITH foxa2 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH foxa2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process axial mesoderm morphogenesis (more)
    Cellular Component nucleus (more)
    Molecular Function sequence-specific DNA binding (more)
    GO Terms (all 19)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Conserved_site IPR018122 Fork head domain conserved site1
    Conserved_site IPR030456 Fork head domain conserved site 2
    Domain IPR001766 Fork head domain
    Domain IPR013638 Fork-head N-terminal
    Domain IPR018533 Forkhead box protein, C-terminal
    Homologous_superfamily IPR036388 Winged helix-like DNA-binding domain superfamily
    Homologous_superfamily IPR036390 Winged helix DNA-binding domain superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA foxa2-201 (1)    Ensembl 1772
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM foxa2
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(foxa2-E1B:EGFP) E1Bfoxa2 EGFP Danio rerio 1 2
    MARKER RELATIONSHIPS
    foxa2 Contained in: [BAC] DKEY-208C12 (1) (order this)
    foxa2 Encodes: [EST] fe05g04 (1), tdsubc_2g8
    [cDNA] MGC:101552 (1), MGC:192923 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_130949 (1) 1713 nt
    Genomic GenBank:CR628331 (1) 92644 nt
    Select Tool
    Polypeptide UniProtKB:F1Q819 (1) 409 aa
    Sequence Information (all 20)
    ORTHOLOGY for foxa2 ( Chr: 17 )
    CITATIONS (259)