ZFIN ID: ZDB-GENE-980526-403
Gene Name: NK2 homeobox 2a
Gene Symbol: nkx2.2a    Nomenclature History

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Previous Names: nk2.2, nkx2-2, nkx2.2, id:ibd5090 (1), wu:fc83b01, zgc:136536

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription factor activity and RNA polymerase II proximal promoter sequence-specific DNA binding activity. Involved in endocrine pancreas development and nervous system development. Predicted to localize to the nucleus. Is expressed in several structures, including central nervous system; digestive system; neural keel; neural rod; and neural tube. Orthologous to human NKX2-2 (NK2 homeobox 2).
Genome Resources: Alliance (1),  Gene:30697 (1),  Ensembl(GRCz11):ENSDARG00000053298 (2)
GENE EXPRESSION
All Expression Data: 143 figures from 90 publications
Directly Submitted Expression Data: 3 figures (3 images) from Kudoh et al., 2001 [ibd5090]
  6 figures (8 images) from Thisse et al., 2004 [IMAGE:6912071]
Wild-type Stages, Structures: Gastrula:75%-epiboly (8.0h-9.0h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa23158 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-nkx2.2a N/A 1
    MO2-nkx2.2a N/A 1
    MO3-nkx2.2a N/A 3
    MO4-nkx2.2a N/A 4
    MO5-nkx2.2a N/A 2
    MO6-nkx2.2a N/A 1
    DISEASE ASSOCIATED WITH nkx2.2a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH nkx2.2a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process ventral spinal cord interneuron differentiation (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 18)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR001356 Homeobox domain
    Homologous_superfamily IPR009057 Homeobox-like domain superfamily
    Conserved_site IPR017970 Homeobox, conserved site
    Domain IPR020479 Homeobox domain, metazoa
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA nkx2.2a-201 (1)    Ensembl 1555
    nkx2.2a-202 (1)    Ensembl 1730
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM nkx2.2a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(-3.5nkx2.2a:GFP) nkx2.2a GFP Danio rerio 1 13
    Tg(-8.5nkx2.2a:GFP) nkx2.2a GFP Danio rerio 1 5
    Tg(nkx2.2a:mEGFP) nkx2.2a EGFP Danio rerio 2 58
    MARKER RELATIONSHIPS
    nkx2.2a Contained in: [BAC] DKEY-89L19 (1) (order this)
    nkx2.2a Encodes: [EST] fc83b01 (1), ibd5090 (1), IMAGE:6912071 (1)
    [cDNA] MGC:100783 (1), MGC:136536 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131422 (1) 1576 bp
    Genomic GenBank:BX927409 (1) 154287 bp
    Select Tool
    Polypeptide UniProtKB:F1QNE4 (1) 273 aa
    Sequence Clusters UniGene:75083 (1)
    Sequence Information (all 22)
    ORTHOLOGY for nkx2.2a ( Chr: 17 )
    CITATIONS (163)