ZFIN ID: ZDB-GENE-980526-403
Gene Name: NK2 homeobox 2a
Gene Symbol: nkx2.2a
Sequence Ontology ID : SO:0000704

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Previous Names: nk2.2, nkx2-2, nkx2.2, id:ibd5090 (1), wu:fc83b01, zgc:136536

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(Including Attributions)
Location: Chr: 17 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have sequence-specific DNA binding activity; involved in several processes, including animal organ development, animal organ development, and nervous system development; predicted to  ...
GENE EXPRESSION
All Expression Data: 142 figures from 89 publications
Directly Submitted Expression Data: 3 figures (3 images) from Kudoh et al., 2001 [ibd5090]
  6 figures (8 images) from Thisse et al., 2004 [IMAGE:6912071]
Wild-type Stages, Structures: Gastrula:75%-epiboly (8.0h-9.0h) to Adult (90d-730d, breeding adult)
 
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa23158 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents:
    PHENOTYPE
    Data: 13 figures from 5 publications
    Observed in:
    DISEASE ASSOCIATED WITH nkx2.2a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH nkx2.2a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process ventral spinal cord interneuron differentiation (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001356 (1)
  • InterPro:IPR009057 (1)
  • InterPro:IPR017970 (1)
  • InterPro:IPR020479 (1)
  • PROSITE:PS00027 (1)
  • PROSITE:PS50071 (1)
  • Pfam:PF00046 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA nkx2.2a-201 (1) 1555
    nkx2.2a-202 (1) 1730
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM nkx2.2a
    MARKER RELATIONSHIPS
    nkx2.2aContained in: [BAC] DKEY-89L19 (1) (order this)
    nkx2.2aEncodes: [EST] fc83b01 (1), ibd5090 (1) (order this), IMAGE:6912071 (1) (order this)
    [cDNA] MGC:100783 (1) (order this), MGC:136536 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131422 (1) 1576bp
    Genomic GenBank:BX927409 (1) 154287bp
    Select Tool
    Polypeptide UniProtKB:F1QNE4 (1) 273aa
    Sequence Clusters UniGene:75083 (1)
    Sequence Information (all 22)
    OTHER nkx2.2a GENE PAGES
  • Alliance (1)
  • Gene:30697 (1)
  • VEGA:OTTDARG00000020535 (1)
  • Ensembl(GRCz11):ENSDARG00000053298 (2)
  • ORTHOLOGY for nkx2.2a (Chr: 17)
    CITATIONS (159)