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ZIRC
ZFIN ID: ZDB-GENE-980526-397
Gene Name: prospero homeobox 1a
Gene Symbol: prox1a    Nomenclature History

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Previous Names: prox1 (1), zgc:111888

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Predicted to have DNA binding activity. Involved in several processes, including lymphangiogenesis; negative regulation of DNA-binding transcription factor activity; and neuromast development. Localizes to the nucleus. Is expressed in several structures, including digestive system; mesoderm; nervous system; pleuroperitoneal region; and trunk vasculature. Orthologous to human PROX1 (prospero homeobox 1).
Genome Resources: Alliance (1),  Gene:30679 (1),  Ensembl(GRCz11):ENSDARG00000055158 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
i278 Indel Unknown Frameshift, Premature Stop ZINC_FINGER_NUCLEASE
la027849Tg Transgenic Insertion Unknown Unknown DNA
sa23123 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa23124 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-prox1a N/A 10
    MO2-prox1a N/A 1
    MO3-prox1a N/A 2
    DISEASE ASSOCIATED WITH prox1a HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH prox1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process negative regulation of DNA-binding transcription factor activity (more)
    Cellular Component nucleus (more)
    Molecular Function DNA binding (more)
    GO Terms (all 11)
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA prox1a-201 (1)    Ensembl 3008
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab4-prox1 polyclonal IgG Goat IHC R&D Systems
    5
    Ab5-prox1 polyclonal IgG Rabbit IHC AngioBio
    14
    Ab7-prox1 polyclonal Rabbit IHC RELIA Tech
    5
    Ab2-Prox1 polyclonal Rabbit IHC 3
    Ab6-prox1 polyclonal Rabbit IHC 7
    Ab3-prox1 polyclonal Rabbit IHC Millipore
    41
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM prox1a
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    TgBAC(prox1a:Citrine) prox1a Citrine Danio rerio 1 4
    TgBAC(prox1a:KALTA4) prox1a KALTA4 Danio rerio 1 2
    TgBAC(prox1a:KALTA4,4xUAS-E1B:TagRFP) E1Bprox1aUAS KALTA4TagRFP Danio rerio 1 24
    MARKER RELATIONSHIPS
    prox1a Contained in: [BAC] DKEY-5J3 (1) (order this)
    prox1a Encodes: [EST] eu351 (1)
    [cDNA] MGC:111888 (1) (order this), MGC:191746 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131405 (1) 2839 bp
    Genomic GenBank:BX928753 (1) 73008 bp
    Select Tool
    Polypeptide UniProtKB:F1QAE1 (1) 739 aa
    Sequence Clusters UniGene:81273 (1)
    Sequence Information (all 29)
    ORTHOLOGY for prox1a ( Chr: 17 )
    CITATIONS (187)