ZFIN ID: ZDB-GENE-980526-389
Gene Name: growth differentiation factor 3
Gene Symbol: gdf3    Nomenclature History

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Previous Names: cb556 (1), dvr1, vg1 (2), zDVR-1, zDVR1, zgc:103542

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 17 Mapping Details/Browsers
Description: Predicted to have cytokine activity. Involved in several processes, including embryonic morphogenesis; regulation of nodal signaling pathway involved in determination of left/right asymmetry; and transmembrane receptor protein serine/threonine kinase signaling pathway. Localizes to protein-containing complex. Human ortholog(s) of this gene implicated in Klippel-Feil syndrome 3; dextro-looped transposition of the great arteries 3; isolated microphthalmia 7; and visceral heterotaxy. Is expressed in several structures, including heart primordium; mesoderm; oocyte; somite; and tail bud. Orthologous to several human genes including GDF3 (growth differentiation factor 3).
Genome Resources: Alliance (1),  Gene:30125 (1),  Ensembl(GRCz11):ENSDARG00000037995 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
a164 Small Deletion Exon 1 Unknown CRISPR
a165 Small Deletion Exon 1 Unknown CRISPR
fb20a Small Deletion Exon 2 Frameshift, Premature Stop CRISPR
pr05 Small Deletion Exon 1 Frameshift, Premature Stop CRISPR
pr06 Indel Unknown Unknown CRISPR
pr11 Indel Exon 1 Frameshift, Premature Stop CRISPR
sa22982 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • zy51 Small Deletion Exon 1 Frameshift, Premature Stop TALEN
    zy52 Small Deletion Exon 1 Frameshift, Premature Stop TALEN
    zy53 Small Deletion Unknown Inframe Deletion TALEN
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-gdf3 1
    CRISPR2-gdf3 2
    CRISPR3-gdf3 1
    MO1-gdf3 N/A 1
    MO2-gdf3 N/A 4
    MO3-gdf3 N/A 1
    MO4-gdf3 N/A 1
    MO5-gdf3 N/A 1
    TALEN1-gdf3 1
    PHENOTYPE
    Data: 22 figures from 8 publications
    Observed in:
    DISEASE ASSOCIATED WITH gdf3 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    isolated microphthalmia 7 Alliance Microphthalmia, isolated 7 613704
    Klippel-Feil syndrome 3 Alliance Klippel-Feil syndrome 3, autosomal dominant 613702
    Microphthalmia with coloboma 6 613703
    DISEASE ASSOCIATED WITH gdf3 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process convergent extension involved in gastrulation (more)
    Cellular Component protein-containing complex (more)
    Molecular Function growth factor activity (more)
    GO Terms (all 20)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA gdf3-201 (1)    Ensembl 1255
    gdf3-202 (1)    Ensembl 1519
    gdf3-203 (1)    Ensembl 803
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gdf3 No data available
    MARKER RELATIONSHIPS
    gdf3 Contained in: [Fosmid] ZFOS-1139C7 (1)
    gdf3 Encodes: [EST] cb556 (1) (order this)
    [cDNA] MGC:103542 (1), MGC:191347 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_130948 (1) 1243 nt
    Genomic GenBank:FP101972 (1) 25835 nt
    Select Tool
    Polypeptide UniProtKB:P35621 (1) 355 aa
    Sequence Information (all 27)
    ORTHOLOGY for gdf3 ( Chr: 17 )
    CITATIONS (53)