ZFIN ID: ZDB-GENE-980526-352
Gene Name: wingless-type MMTV integration site family, member 4
Gene Symbol: wnt4    Nomenclature History

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Previous Names: wnt4a, ZfWnt4 (1), zgc:136737

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 11 Mapping Details/Browsers
Description: Predicted to have frizzled binding activity. Involved in several processes, including animal organ development; regulation of axon extension involved in axon guidance; and sensory epithelium regeneration. Predicted to localize to the extracellular space. Is expressed in several structures, including central nervous system; head; neural rod; neural tube; and pleuroperitoneal region. Orthologous to human WNT4 (Wnt family member 4).
Genome Resources: Alliance (1),  Gene:30123 (1),  Ensembl(GRCz11):ENSDARG00000071208 (2)
Note: zebrafish wnt4 is the only ortholog of human WNT4 in zebrafish. Teleost wnt4b is a VGD ohnolog gone missing from humans. Teleosts, gar, coelacanth, and some birds and lizard have orthologs of both wnt4a and wnt4b
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
fh294 Point Mutation Unknown Unknown ENU
  • China Zebrafish Resource Center (CZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • fh295 Point Mutation Unknown Unknown ENU
    sa14222 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • wnt4_unrecovered Point Mutation Unknown Unknown ENU
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-wnt4 N/A 5
    MO2-wnt4 N/A 1
    MO3-wnt4 N/A 2
    MO4-wnt4 N/A 1
    DISEASE ASSOCIATED WITH wnt4 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Mullerian aplasia and hyperandrogenism Alliance Mullerian aplasia and hyperandrogenism 158330
    ?SERKAL syndrome 611812
    DISEASE ASSOCIATED WITH wnt4 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process positive regulation of transcription, DNA-templated (more)
    Cellular Component extracellular region (more)
    Molecular Function signaling receptor binding (more)
    GO Terms (all 15)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Conserved_site IPR018161 Wnt protein, conserved site
    Family IPR005817 Wnt
    Family IPR009142 Wnt-4 protein
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA wnt4a-201 (1)    Ensembl 2242
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM wnt4
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(UAS:wnt4,cryaa:Cerulean) cryaaUAS Ceruleanwnt4 Danio rerio 1 3
    MARKER RELATIONSHIPS
    wnt4 Contained in: [BAC] CH211-146F2 (1), DKEY-208K8 (1) (order this)
    wnt4 Contains: [SNP] rs3728403 (1)
    wnt4 Encodes: [EST] eu648 (1)
    [cDNA] MGC:136737 (1), MGC:194977 (1), MGC:194994 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001040387 (1) 2264 nt
    Genomic GenBank:CR926911 158622 nt
    Select Tool
    Polypeptide UniProtKB:A0A0B5JFI1 (1) 352 aa
    Sequence Information (all 30)
    ORTHOLOGY for wnt4 ( Chr: 11 )
    CITATIONS (68)