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Gene

wnt4

ID
ZDB-GENE-980526-352
Name
wingless-type MMTV integration site family, member 4
Symbol
wnt4 Nomenclature History
Previous Names
  • wnt4a
  • ZfWnt4 (1)
  • zgc:136737
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Predicted to enable cytokine activity and frizzled binding activity. Acts upstream of or within several processes, including animal organ development; regulation of axon extension involved in axon guidance; and sensory epithelium regeneration. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including central nervous system; head; neural rod; neural tube; and reproductive system. Human ortholog(s) of this gene implicated in Mullerian aplasia and hyperandrogenism. Orthologous to human WNT4 (Wnt family member 4).
Genome Resources
Note
zebrafish wnt4 is the only ortholog of human WNT4 in zebrafish. Teleost wnt4b is a VGD ohnolog gone missing from humans. Teleosts, gar, coelacanth, and some birds and lizard have orthologs of both wnt4a and wnt4b
Comparative Information
Expression
All Expression Data
31 figures from 18 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
7 figures from 5 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With wnt4 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Mullerian aplasia and hyperandrogenism Alliance Mullerian aplasia and hyperandrogenism 158330
?SERKAL syndrome 611812
Associated With wnt4 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR018161 Wnt protein, conserved site
Family IPR005817 Wnt
Family IPR009142 Wnt-4 protein
Homologous_superfamily IPR043158 Wnt, C-terminal domain
Domain Details Per Protein
Protein Length Wnt Wnt-4 protein Wnt, C-terminal domain Wnt protein, conserved site
UniProtKB:Q1RLW9 352
UniProtKB:P47793 352
UniProtKB:A0A0B5JFI1 352
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations