ZFIN ID: ZDB-GENE-980526-307
Gene Name: ret proto-oncogene receptor tyrosine kinase
Gene Symbol: ret
Previous Names: c-ret (1), cret, etID315074.13 (1), ret1, wu:fd13h01
Location: Chr: 13 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 36 figures from 25 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
  adductor operculi myoblast, anterior lateral line ganglion, brain, central nervous system (all 26) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS 
Allele Type Mutagen Suppliers
hu2846 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la018487Tg Transgenic Insertion DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa2684 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15240 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa22307 Point Mutation ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents: MO1-ret (1), MO2-ret (1), MO3-ret (1), MO4-ret (1), MO5-ret (1)
    PHENOTYPE
    Data: 9 figures from 7 publications
    Observed in: abductor hyohyoid, adductor hyohyoid, adductor operculi, branchiomeric skeletal muscle development (all 16) expand
    DISEASE ASSOCIATED WITH ret HUMAN ORTHOLOG 
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    familial medullary thyroid carcinoma Medullary thyroid carcinoma 155240
    Hirschsprung's disease {Hirschsprung disease, susceptibility to, 1} 142623
    multiple endocrine neoplasia type 2A Multiple endocrine neoplasia IIA 171400
    multiple endocrine neoplasia type 2B Multiple endocrine neoplasia IIB 162300
    phaeochromocytoma Pheochromocytoma 171300
    renal agenesis Renal agenesis 191830
    Central hypoventilation syndrome, congenital 209880
    GENE ONTOLOGY 
    Ontology GO Term
    Biological Process enteric nervous system development (more)
    Cellular Component membrane (more)
    Molecular Function ATP binding (more)
    GO Terms (all 13)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000719 (1)
  • InterPro:IPR001245 (1)
  • InterPro:IPR002126 (1)
  • InterPro:IPR008266 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR015919 (1)
  • InterPro:IPR016249 (1)
  • InterPro:IPR017441 (1)
  • InterPro:IPR020635 (1)
  • PROSITE:PS00107 (1)
  • PROSITE:PS00109 (1)
  • PROSITE:PS50011 (1)
  • PROSITE:PS50268 (1)
  • Pfam:PF00028 (1)
  • Pfam:PF07714 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA ret-001 (1) 4230
    ret-002 (1) 5094
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ret
    Tg(ret1:GFP)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS 
    retContained in: [BAC] DKEY-192P21 (1) (order this)
    retEncodes: [EST] fd13h01
    SEQUENCE INFORMATION 
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_181662 (1) 4126bp
    Genomic GenBank:AC124155 (1) 173037bp
    Select Tool
    Polypeptide UniProtKB:A8E7C6 (1) 1106aa
    Sequence Clusters UniGene:75763 (1)
    Sequence Information (all 20)
    OTHER ret GENE PAGES 
  • Gene:30512 (1)
  • VEGA:OTTDARG00000017726 (1)
  • Ensembl(GRCz10):ENSDARG00000055305 (1)
  • ORTHOLOGY for ret (Chr: 13) 
    Species Symbol Chromosome Accession # Evidence
    Human RET 10
  • Gene:5979
  • OMIM:164761
  • HGNC:9967
  • Amino acid sequence comparison (2)
    Conserved genome location (synteny) (4)
    Mouse Ret 6
  • MGI:97902
  • Gene:19713
  • Amino acid sequence comparison (1)
    Download Curated Orthology
    CITATIONS (65)