Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-980526-307
Gene Name: ret proto-oncogene receptor tyrosine kinase
Gene Symbol: ret
Previous Names: cret, ret1, etID315074.13 (1), wu:fd13h01
Location: Chr: 13   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 33 figures from 23 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
  adductor operculi myoblast, anterior lateral line ganglion, brain, central nervous system (all 22) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 4 genotypes
Alleles: hu2846, la018487Tg, sa15240, sa22307, sa2684
Knockdown reagents: MO1-ret (1), MO2-ret (1), MO3-ret (1), MO4-ret (1), MO5-ret (1)
PHENOTYPE
Data: 7 figures from 5 publications
Observed in: abductor hyohyoid, adductor hyohyoid, adductor operculi, branchiomeric skeletal muscle development (all 15) expand

Phenotype of Human Orthologue OMIM Phenotype ID
Central hypoventilation syndrome, congenital 209880
Medullary thyroid carcinoma 155240
Multiple endocrine neoplasia IIA 171400
Multiple endocrine neoplasia IIB 162300
Pheochromocytoma 171300
Renal agenesis 191830
{Hirschsprung disease, susceptibility to, 1} 142623
GENE ONTOLOGY
Ontology GO Term
Biological Process branchiomeric skeletal muscle development (more)
Cellular Component integral component of membrane (more)
Molecular Function ATP binding (more)
GO Terms (all 15)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000719 (1)
  • InterPro:IPR001245 (1)
  • InterPro:IPR002126 (1)
  • InterPro:IPR008266 (1)
  • InterPro:IPR011009 (1)
  • InterPro:IPR015919 (1)
  • InterPro:IPR016249 (1)
  • InterPro:IPR017441 (1)
  • InterPro:IPR020635 (1)
  • PROSITE:PS00107 (1)
  • PROSITE:PS00109 (1)
  • PROSITE:PS50011 (1)
  • PROSITE:PS50268 (1)
  • Pfam:PF07714 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA ret-001 (1) 4230
    ret-002 (1) 5094
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    CONSTRUCTS WITH SEQUENCES FROM ret
    Tg(ret1:GFP)
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    ret Contained in: [BAC] DKEY-192P21 (1)
    ret Encodes: [EST] fd13h01
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_181662 (1) 4126 bp
    Genomic GenBank:AC124155 (1) 173037 bp
    Select Tool
    Polypeptide UniProtKB:A8E7C6 (1) 1106 aa
    Sequence Clusters UniGene:75763 (1)
    Sequence Information (all 17)
    OTHER ret GENE PAGES
  • Gene:30512 (1)
  • VEGA:OTTDARG00000017726 (1)
  • Ensembl(Zv9):ENSDARG00000055305 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish ret 13  
    Human RET 10 (10q11.2)
  • OMIM:164761
  • Gene:5979
  • Mouse Ret 6 ( 55.86 cM)
  • MGI:97902
  • Gene:19713
  • Orthology Details
    CITATIONS (62)