Gene

ret

ID
ZDB-GENE-980526-307
Name
ret proto-oncogene receptor tyrosine kinase
Symbol
ret Nomenclature History
Previous Names
  • c-ret (1)
  • cret
  • etID315074.13 (1)
  • ret1
  • wu:fd13h01
Type
protein_coding_gene
Location
Chr: 13 Mapping Details/Browsers
Description
Exhibits protein homodimerization activity. Involved in several processes, including autonomic nervous system development; branchiomeric skeletal muscle development; and pronephros morphogenesis. Predicted to localize to axon; integral component of plasma membrane; and receptor complex. Is expressed in nervous system; pharyngeal arch; presumptive enteric nervous system; pronephric duct; and vagal neural crest. Used to study Hirschsprung's disease. Human ortholog(s) of this gene implicated in several diseases, including Hirschsprung's disease; congenital central hypoventilation syndrome; familial medullary thyroid carcinoma; multiple endocrine neoplasia type 2A; and multiple endocrine neoplasia type 2B. Orthologous to human RET (ret proto-oncogene).
Genome Resources
Note
None
Expression
All Expression Data
39 figures from 28 publications
Cross-Species Comparison
High Throughput Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
22 figures from 11 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ret Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
congenital central hypoventilation syndrome Alliance Central hypoventilation syndrome, congenital 209880
familial medullary thyroid carcinoma Alliance Medullary thyroid carcinoma 155240
multiple endocrine neoplasia type 2A Alliance Multiple endocrine neoplasia IIA 171400
multiple endocrine neoplasia type 2B Alliance Multiple endocrine neoplasia IIB 162300
pheochromocytoma Alliance Pheochromocytoma 171300
{Hirschsprung disease, protection against} 142623
{Hirschsprung disease, susceptibility to, 1} 142623
Associated With ret Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008266 Tyrosine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
Domain IPR002126 Cadherin-like
Domain IPR020635 Tyrosine-protein kinase, catalytic domain
Domain IPR040667 Tyrosine-protein kinase receptor Ret, cadherin like domain 3
Domain IPR041163 Ret, cadherin like domain 1
Domain IPR041317 RET cadherin-like domain 4
Family IPR016249 Tyrosine-protein kinase, Ret receptor
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR015919 Cadherin-like superfamily
Domain Details Per Protein
Protein Length Cadherin-like Cadherin-like superfamily Protein kinase, ATP binding site Protein kinase domain Protein kinase-like domain superfamily Ret, cadherin like domain 1 RET cadherin-like domain 4 Serine-threonine/tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase, active site Tyrosine-protein kinase, catalytic domain Tyrosine-protein kinase receptor Ret, cadherin like domain 3 Tyrosine-protein kinase, Ret receptor
UniProtKB:A0A0B5JW56 633
UniProtKB:O42362 1106
UniProtKB:F1R376 1064
UniProtKB:D6QWX7 38
UniProtKB:A8E7C6 1106
UniProtKB:P79726 1106
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
Name Type Antigen Genes Isotype Host Organism Assay Source Citations
Ab1-ret polyclonal Rabbit
  • IHC
  • WB
Santa Cruz Biotechnology, Inc.
4
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Ensembl Gene Tree
Citations