ZFIN ID: ZDB-GENE-980526-307
Gene Name: ret proto-oncogene receptor tyrosine kinase
Gene Symbol: ret
Sequence Ontology ID : SO:0000704

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: c-ret (1), cret, etID315074.13 (1), ret1, wu:fd13h01

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Location: Chr: 13 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 37 figures from 26 publications
Wild-type Stages, Structures: Zygote:1-cell (0.0h-0.75h) to Adult (90d-730d, breeding adult)
  adductor operculi myoblast, anterior lateral line ganglion, brain, central nervous system (all 27) expand
Curated Microarray Expression: GEO (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu2846 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la018487Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa2684 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15240 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa22307 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa35492 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42210 Point Mutation Unknown Premature Stop ENU
    Targeting reagents: CRISPR1-ret (1), MO1-ret (1), MO2-ret (1), MO3-ret (1), MO4-ret (1) (all 6) expand
    PHENOTYPE
    Data: 15 figures from 9 publications
    Observed in: abductor hyohyoid, adductor hyohyoid, adductor operculi, branchiomeric skeletal muscle development (all 23) expand
    DISEASE ASSOCIATED WITH ret HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    congenital central hypoventilation syndrome Central hypoventilation syndrome, congenital 209880
    familial medullary thyroid carcinoma Medullary thyroid carcinoma 155240
    multiple endocrine neoplasia type 2A Multiple endocrine neoplasia IIA 171400
    multiple endocrine neoplasia type 2B Multiple endocrine neoplasia IIB 162300
    phaeochromocytoma Pheochromocytoma 171300
    {Hirschsprung disease, susceptibility to, 1} 142623
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process enteric nervous system development (more)
    Cellular Component membrane (more)
    Molecular Function ATP binding (more)
    GO Terms (all 19)
    PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000719
  • InterPro:IPR001245
  • InterPro:IPR002126
  • InterPro:IPR008266
  • InterPro:IPR011009
  • InterPro:IPR015919
  • InterPro:IPR016249
  • InterPro:IPR017441
  • InterPro:IPR020635
  • PROSITE:PS00107
  • PROSITE:PS00109
  • PROSITE:PS50011
  • PROSITE:PS50268 (1)
  • Pfam:PF00028
  • Pfam:PF07714
  • EC:2.7.10.1
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA ret-001 (1) 4230
    ret-002 (1) 5094
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM ret
    Tg(ret1:GFP)
    MARKER RELATIONSHIPS
    retContained in: [BAC] DKEY-192P21 (1) (order this)
    retEncodes: [EST] fd13h01
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_181662 (1) 4126bp
    Genomic GenBank:AC124155 (1) 173037bp
    Select Tool
    Polypeptide UniProtKB:A8E7C6 1106aa
    Sequence Clusters UniGene:75763 (1)
    Sequence Information (all 24)
    OTHER ret GENE PAGES
  • Alliance (1)
  • Gene:30512 (1)
  • VEGA:OTTDARG00000017726 (1)
  • Ensembl(GRCz10):ENSDARG00000055305 (1)
  • ORTHOLOGY for ret (Chr: 13)
    CITATIONS (75)