ZFIN ID: ZDB-GENE-980526-307
Gene Name: ret proto-oncogene receptor tyrosine kinase
Gene Symbol: ret    Nomenclature History

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Previous Names: c-ret (1), cret, etID315074.13 (1), ret1, wu:fd13h01

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Exhibits protein homodimerization activity. Involved in several processes, including autonomic nervous system development; branchiomeric skeletal muscle development; and pronephros morphogenesis. Predicted to localize to the axon; integral component of plasma membrane; and receptor complex. Used to study Hirschsprung's disease. Human ortholog(s) of this gene implicated in several diseases, including Hirschsprung's disease; congenital central hypoventilation syndrome; familial medullary thyroid carcinoma; multiple endocrine neoplasia type 2A; and multiple endocrine neoplasia type 2B. Is expressed in nervous system; pharyngeal arch; presumptive enteric nervous system; pronephric duct; and vagal neural crest. Orthologous to human RET (ret proto-oncogene).
Genome Resources: Alliance (1),  Gene:30512 (1),  Ensembl(GRCz11):ENSDARG00000055305 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
hu2846 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • ihb309 Small Deletion Exon 4 Unknown CRISPR
    ihb310 Indel Exon 4 Unknown CRISPR
    la018487Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa2684 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa15240 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa22307 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa35492 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42210 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-ret
    1
    CRISPR2-ret 1
    MO1-ret N/A 2
    MO2-ret N/A 6
    MO3-ret N/A 3
    MO4-ret N/A 1
    MO5-ret N/A 1
    DISEASE ASSOCIATED WITH ret HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    congenital central hypoventilation syndrome Alliance Central hypoventilation syndrome, congenital 209880
    familial medullary thyroid carcinoma Alliance Medullary thyroid carcinoma 155240
    multiple endocrine neoplasia type 2A Alliance Multiple endocrine neoplasia IIA 171400
    multiple endocrine neoplasia type 2B Alliance Multiple endocrine neoplasia IIB 162300
    pheochromocytoma Alliance Pheochromocytoma 171300
    {Hirschsprung disease, protection against} 142623
    {Hirschsprung disease, susceptibility to, 1} 142623
    DISEASE ASSOCIATED WITH ret VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    Hirschsprung's disease rethu2846/+ standard conditions Heanue et al., 2016
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process protein-containing complex assembly (more)
    Cellular Component membrane (more)
    Molecular Function protein binding (more)
    GO Terms (all 28)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Domain IPR000719 Protein kinase domain
    Domain IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
    Domain IPR002126 Cadherin-like
    Active_site IPR008266 Tyrosine-protein kinase, active site
    Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
    Homologous_superfamily IPR015919 Cadherin-like superfamily
    Family IPR016249 Tyrosine-protein kinase, Ret receptor
    Binding_site IPR017441 Protein kinase, ATP binding site
    Domain IPR020635 Tyrosine-protein kinase, catalytic domain
    Domain IPR040667 Tyrosine-protein kinase receptor Ret, cadherin like domain 3
    Domain IPR041163 Ret, cadherin like domain 1
    Domain IPR041317 RET cadherin-like domain 4
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ret-201 (1)    Ensembl 4230
    ret-202 (1)    Ensembl 5094
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ret
    Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
    Tg(ret1:GFP) ret GFP Danio rerio 1 5
    MARKER RELATIONSHIPS
    ret Contained in: [BAC] DKEY-192P21 (1) (order this)
    ret Encodes: [EST] fd13h01
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_181662 (1) 4145 bp
    Genomic GenBank:AC124155 (1) 173037 bp
    Select Tool
    Polypeptide UniProtKB:A8E7C6 (1) 1106 aa
    Sequence Clusters UniGene:75763 (1)
    Sequence Information (all 24)
    ORTHOLOGY for ret ( Chr: 13 )
    CITATIONS (92)