ZFIN Gene: msx3

ZFIN ID: ZDB-GENE-980526-306

ZFIN ID: ZDB-GENE-980526-306

Gene Name:

muscle segment homeobox 3

Gene Symbol:

msx3

Sequence Ontology ID :

SO:0000704

Previous Names:

msx-c, msxc (1), etID309953.13 (1), msh-C, mshC, zgc:86596 (1)

Location:

Chr: 13 Mapping Details/Browsers

Nomenclature History

AUTOMATED DESCRIPTION

Predicted to have RNA polymerase II regulatory region sequence-specific DNA binding activity. Involved in otic placode formation. Predicted to localize to the nucleus. Human ortholog(s) of this gene ...

GENE EXPRESSION
All Expression Data:	69 figures from 44 publications
Directly Submitted Expression Data:	7 figures (19 images) from Thisse et al., 2005 [eu507]
Wild-type Stages, Structures:	Gastrula:75%-epiboly (8.0h-9.0h) to Adult (90d-730d, breeding adult)
	anterior crista anterior crista primordium ball epidermis brain dorsal region central nervous system epiblast epidermis fin fold pectoral fin bud heart hindbrain neural keel hypoblast immature eye lateral crista lateral crista primordium macula median fin fold mesenchyme median fin fold mesenchyme pectoral fin anterior region mesenchyme pectoral fin midbrain neural rod neural crest neural crest cell neural plate neural tube neuroectoderm dorsal region optic cup postero-dorsal region optic vesicle otic placode otic vesicle otic vesicle protrusion pectoral fin pectoral fin bud anterior region pectoral fin bud apical margin pectoral fin bud distal margin pectoral fin bud mesenchyme pectoral fin bud pelvic fin bud posterior crista posterior crista primordium posterior neural tube presumptive cephalic mesoderm presumptive neural retina presumptive pronephric mesoderm retina roof plate spinal cord region spinal cord tail bud unspecified vent whole organism dorsal region whole organism ventral region
Curated Microarray Expression:	GEO (1)

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
ihb246	Indel	Exon 1	Unknown	CRISPR	China Zebrafish Resource Center (CZRC) (order this)
mn0245Gt	Transgenic Insertion	Unknown	Unknown	DNA	Zebrafish International Resource Center (ZIRC) (order this)
tud18Gt	Transgenic Insertion	Exon 1	Unknown	DNA	European Zebrafish Resource Center (EZRC) (order this)

Targeting reagents:

CRISPR1-msx3 (1)
MO1-msx3 (1)

PHENOTYPE

Data:	2 figures from Phillips et al., 2006
Observed in:	cartilage development cranial cartilage embryonic viscerocranium morphogenesis post-vent region

DISEASE ASSOCIATED WITH msx3 HUMAN ORTHOLOG No data available

DISEASE ASSOCIATED WITH msx3 VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Biological Process	otic placode formation (more)
Cellular Component	nucleus (more)
Molecular Function	DNA binding (more)

GO Terms (all 8)

PROTEIN FAMILIES, DOMAINS AND SITES
InterPro:IPR001356 (1) InterPro:IPR009057 (1) InterPro:IPR017970 (1) InterPro:IPR020479 (1)	PROSITE:PS00027 (1) PROSITE:PS50071 (1)	Pfam:PF00046 (1)

TRANSCRIPTS
Type	Name	Length (bp)	Analysis
mRNA	msx3-201 (1)	2028	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

GENE PRODUCT DESCRIPTION

INTERACTIONS AND PATHWAYS

ANTIBODIESNo data available

PLASMIDSNo data available

CONSTRUCTS WITH SEQUENCES FROM msx3

Tg(msx3:DsRed2)

MARKER RELATIONSHIPS

msx3Contained in:	[BAC] CH211-217G15 (1) (order this), DKEYP-85D1
msx3Encodes:	[EST] eu507 (1), fc66g03 (1) [cDNA] MGC:86596 (order this)

SEQUENCE INFORMATION

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_131272 (1)	944bp	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CR589879	201310bp	Blast at MegaBLAST
Polypeptide	UniProtKB:Q6IQV1 (1)	274aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast
Sequence Clusters	UniGene:32741 (1)

Sequence Information (all 24)

OTHER msx3 GENE PAGES

Alliance (1)

Gene:30526 (1)

VEGA:OTTDARG00000001892 (1)

Ensembl(GRCz11):ENSDARG00000015674 (2)

ORTHOLOGY for msx3 (Chr: 13)

CITATIONS (106)

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