ZFIN ID: ZDB-GENE-980526-299
Gene Name: hematopoietically expressed homeobox
Gene Symbol: hhex    Nomenclature History

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Previous Name: hex

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Predicted to have DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including animal organ development; positive regulation of endothelial cell differentiation; and vasculature development. Predicted to localize to nucleus. Is expressed in several structures, including cardiovascular system; digestive system; endocrine system; hepatoblast; and mesoderm. Orthologous to human HHEX (hematopoietically expressed homeobox).
Genome Resources: Alliance (1),  Gene:30098 (1),  Ensembl(GRCz11):ENSDARG00000098231 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
s721 Insertion Unknown Frameshift, Premature Stop TALEN
s722 Small Deletion Unknown Inframe Deletion TALEN
zju16 Small Deletion Unknown Unknown CRISPR
zju17 Small Deletion Unknown Unknown CRISPR
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-hhex 1
MO1-hhex N/A 2
MO2-hhex N/A 2
MO3-hhex N/A 1
TALEN1-hhex 1
DISEASE ASSOCIATED WITH hhex HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH hhex VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process negative regulation of transcription by RNA polymerase II (more)
Cellular Component nucleus (more)
Molecular Function sequence-specific DNA binding (more)
GO Terms (all 24)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS No data available
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM hhex
Construct Regulatory Regions Coding Sequences Species Tg Lines Publications
Tg(fli1:Tomato-2A-hhex) fli1 2AhhexTomato Danio rerio 1 1
MARKER RELATIONSHIPS
hhex Encodes: [cDNA] MGC:193885 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_130934 (1)
Genomic GenBank:CABZ01081547 (1) 7000 nt
Polypeptide UniProtKB:B3DH15 (1) 228 aa
Sequence Information (all 17)
ORTHOLOGY for hhex ( Chr: 12 )
CITATIONS (215)