ZFIN ID: ZDB-GENE-980526-280
Gene Name: distal-less homeobox 3b
Gene Symbol: dlx3b    Nomenclature History

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Previous Names: dlx-3, dlx3, id:ibd3531 (1), wu:fb83f11, zgc:91827

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Exhibits sequence-specific DNA binding activity. Involved in several processes, including sensory organ development; skeletal system development; and trigeminal nerve development. Predicted to localize to nucleus. Is expressed in several structures, including ectoderm; neural plate; neurogenic field; pharyngeal arch; and presumptive structure. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 4 and trichodontoosseous syndrome. Orthologous to human DLX3 (distal-less homeobox 3).
Genome Resources: Alliance (1),  Gene:30585 (1),  Ensembl(GRCz11):ENSDARG00000014626 (2)
GENE EXPRESSION
All Expression Data: 246 figures from 165 publications
Directly Submitted Expression Data: 5 figures (8 images) from Kudoh et al., 2001 [ibd3531]
  6 figures (36 images) from Thisse et al., 2005 [eu221]
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Larval:Days 14-20 (14d-21d, 6.2mm, 10 teeth)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa94 Point Mutation Unknown Missense ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • sa22023 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-dlx3b 1
    MO1-dlx3b N/A 11
    MO2-dlx3b N/A 6
    MO3-dlx3b N/A 2
    MO4-dlx3b N/A 2
    MO5-dlx3b N/A 3
    DISEASE ASSOCIATED WITH dlx3b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    amelogenesis imperfecta type 4 Alliance Amelogenesis imperfecta, type IV 104510
    trichodontoosseous syndrome Alliance Trichodontoosseous syndrome 190320
    DISEASE ASSOCIATED WITH dlx3b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process auditory receptor cell fate specification (more)
    Cellular Component nucleus (more)
    Molecular Function sequence-specific DNA binding (more)
    GO Terms (all 27)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA dlx3b-201 (1)    Ensembl 1591
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM dlx3b No data available
    MARKER RELATIONSHIPS
    dlx3b Contained in: [BAC] CH73-209K3 (1)
    dlx3b Encodes: [EST] eu221 (1), fb83f11, ibd3531 (1)
    [cDNA] MGC:91827 (1), MGC:191167 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131322 (1) 1593 nt
    Genomic GenBank:CU468219 (1) 126695 nt
    Select Tool
    Polypeptide UniProtKB:Q01702 (1) 269 aa
    Sequence Information (all 18)
    ORTHOLOGY for dlx3b ( Chr: 12 )
    CITATIONS (327)