ZFIN Gene: twist2

ZFIN ID: ZDB-GENE-980526-235

ZFIN ID: ZDB-GENE-980526-235

Gene Name:

twist2

Gene Symbol:

twist2

Sequence Ontology ID :

SO:0000704

Previous Names:

dermo1, zgc:101904 (1)

Location:

Chr: 9 Mapping Details/Browsers

Nomenclature History

AUTOMATED DESCRIPTION

Predicted to have protein dimerization activity. Human ortholog(s) of this gene implicated in Barber-Say syndrome; ablepharon macrostomia syndrome; and focal dermal hypoplasia. Orthologous to human ...

GENE EXPRESSION
All Expression Data:	28 figures from 14 publications
Directly Submitted Expression Data:	7 figures (19 images) from Thisse et al., 2004 [MGC:101904]
Wild-type Stages, Structures:	Blastula:1k-cell (3.0h-3.33h) to Larval:Day 5 (120.0h-144.0h, 3.9mm, 6 teeth)
	artery axial chorda mesoderm axial mesoderm axial vasculature brain vasculature cardiovascular system caudal vein plexus chordo neural hinge dorsal aorta forebrain head mesenchyme hindbrain hypochord midbrain notochord notochord posterior region pharyngeal arch pharyngeal vasculature primordial vasculature pronephric mesoderm sclerotome shield somite ventro-medial region tail bud trunk trunk vasculature vertebral column whole organism

MUTATIONS AND SEQUENCE TARGETING REAGENTS

Allele	Type	Localization	Consequence	Mutagen	Suppliers
zf2114	Point Mutation	Unknown	Unknown	CRISPR
zf2115	Indel	Unknown	Unknown	CRISPR

Targeting reagents:

PHENOTYPE No data available

DISEASE ASSOCIATED WITH twist2 HUMAN ORTHOLOG

Disease Ontology Term	OMIM Term	OMIM Phenotype ID
ablepharon macrostomia syndrome	Ablepharon-macrostomia syndrome	200110
Barber-Say syndrome	Barber-Say syndrome	209885
	Focal facial dermal dysplasia 3, Setleis type	227260

DISEASE ASSOCIATED WITH twist2 VIA EXPERIMENTAL MODELS No data available

GENE ONTOLOGY

Ontology	GO Term
Molecular Function	protein dimerization activity (more)

GO Terms (all 1)

PROTEIN FAMILIES, DOMAINS AND SITES
InterPro:IPR011598 (1) InterPro:IPR036638 (1)	PROSITE:PS50888 (1)	Pfam:PF00010 (1)

TRANSCRIPTS
Type	Name	Length (bp)	Analysis
mRNA	twist2-201 (1)	1227	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

GENE PRODUCT DESCRIPTION No description available

INTERACTIONS AND PATHWAYS

ANTIBODIESNo data available

PLASMIDSNo data available

CONSTRUCTS WITH SEQUENCES FROM twist2 No data available

MARKER RELATIONSHIPS

twist2Contained in:	[BAC] CH73-282H7 (1) (order this)
twist2Encodes:	[cDNA] MGC:101904 (1) (order this)

SEQUENCE INFORMATION

Type	Accession #	Length (bp/aa)	Analysis
RNA	RefSeq:NM_001005956 (1)	1054bp	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT
Genomic	GenBank:CU929427 (1)	58358bp	Select Tool MegaBLAST Ensembl
Polypeptide	UniProtKB:Q5XJI8 (1)	163aa	Select Tool ZFIN BLAST SIB BLAST Ensembl Protein Blast
Sequence Clusters	UniGene:36752 (1)

Sequence Information (all 11)

OTHER twist2 GENE PAGES

Alliance (1)

Gene:30395 (1)

VEGA:OTTDARG00000032844 (1)

Ensembl(GRCz11):ENSDARG00000078266 (2)

ORTHOLOGY for twist2 (Chr: 9)

CITATIONS (45)

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