Gene
twist2
- ID
- ZDB-GENE-980526-235
- Name
- twist2
- Symbol
- twist2 Nomenclature History
- Previous Names
-
- dermo1
- zgc:101904 (1)
- Type
- protein_coding_gene
- Location
- Chr: 9 Mapping Details/Browsers
- Description
- Predicted to have DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in developmental process and regulation of transcription by RNA polymerase II. Predicted to localize to nuclear chromatin. Is expressed in several structures, including brain; cardiovascular system; mesoderm; notochord; and tail bud. Human ortholog(s) of this gene implicated in Barber-Say syndrome; ablepharon macrostomia syndrome; and focal dermal hypoplasia. Orthologous to human TWIST2 (twist family bHLH transcription factor 2).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 32 figures from 16 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:101904 (19 images)
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Human Disease | Fish | Conditions | Citations |
---|---|---|---|
ablepharon macrostomia syndrome | twist2zf3421/zf3421 (AB) | standard conditions | Zhao et al., 2020 |
Domain, Family, and Site Summary
Domain Details Per Protein
Protein | Length | Helix-loop-helix DNA-binding domain superfamily | Myc-type, basic helix-loop-helix (bHLH) domain | Twist-related protein 1, basic helix-loop-helix domain |
---|---|---|---|---|
UniProtKB:Q5XJI8
|
163 |
Type | Name | Annotation Method | Length (nt) | Analysis |
---|---|---|---|---|
mRNA |
twist2-201
(1)
|
Havana | 1227 nt |
Interactions and Pathways
No data available
Plasmids
No data available