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General Information
ZIRC
ZFIN ID: ZDB-GENE-980526-235
Gene Name: twist2
Gene Symbol: twist2
Sequence Ontology ID : SO:0001217

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Attributions

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Previous Names: dermo1, zgc:101904 (1)

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(Including Attributions)
Location: Chr: 9 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have protein dimerization activity. Human ortholog(s) of this gene implicated in Barber-Say syndrome; ablepharon macrostomia syndrome; and focal dermal hypoplasia. Is expressed in  ...
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
zf2114 Point Mutation Exon 1 Missense CRISPR
zf2115 MNV Exon 1 Unknown CRISPR
Targeting reagents:
PHENOTYPE
Data: Fig. 3 from Qin et al., 2018
Observed in:
DISEASE ASSOCIATED WITH twist2 HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
ablepharon macrostomia syndrome Ablepharon-macrostomia syndrome 200110
Barber-Say syndrome Barber-Say syndrome 209885
Focal facial dermal dysplasia 3, Setleis type 227260
DISEASE ASSOCIATED WITH twist2 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Molecular Function protein dimerization activity (more)
GO Terms (all 1)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR011598 (1)
  • InterPro:IPR036638 (1)
  • PROSITE:PS50888 (1)
  • Pfam:PF00010 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA twist2-201 (1) 1227
    GENE PRODUCT DESCRIPTION No description available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM twist2 No data available
    MARKER RELATIONSHIPS
    twist2 Contained in: [BAC] CH73-282H7 (1) (order this)
    twist2 Encodes: [cDNA] MGC:101904 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001005956 (1) 1054 bp
    Genomic GenBank:CU929427 (1) 58358 bp
    Select Tool
    Polypeptide UniProtKB:Q5XJI8 (1) 163 aa
    Sequence Clusters UniGene:36752 (1)
    Sequence Information (all 11)
    ORTHOLOGY for twist2 ( Chr: 9 )
    CITATIONS (45)