ZFIN ID: ZDB-GENE-980526-192
Gene Name: collagen, type II, alpha 1a
Gene Symbol: col2a1a
Sequence Ontology ID : SO:0000704

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Previous Names: col2a1, coll2a1, fb38c06, fc10c01, wu:fb38c06 (1), wu:fc10c01

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(Including Attributions)
Location: Chr: 8 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 146 figures from 116 publications
Wild-type Stages, Structures: Gastrula:50%-epiboly (5.25h-5.66h) to Adult (90d-730d, breeding adult)
  anal fin, anal fin pterygiophore, auditory capsule, brain (all 81) expand
Curated Microarray Expression: GEO (1)
PHENOTYPE
Data: 3 figures from 2 publications
Observed in: notochord, post-vent region, regulation of collagen biosynthetic process, whole organism
DISEASE ASSOCIATED WITH col2a1a HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
achondrogenesis type II Achondrogenesis, type II or hypochondrogenesis 200610
Legg-Calve-Perthes disease Legg-Calve-Perthes disease 150600
otospondylomegaepiphyseal dysplasia Otospondylomegaepiphyseal dysplasia 215150
spondyloepimetaphyseal dysplasia, Strudwick type SMED Strudwick type 184250
spondyloepiphyseal dysplasia congenita SED congenita 183900
Stickler syndrome Stickler syndrome, type I 108300
Spondyloepiphyseal dysplasia, Stanescu type 616583
Czech dysplasia 609162
Stickler sydrome, type I, nonsyndromic ocular 609508
Osteoarthritis with mild chondrodysplasia 604864
Kniest dysplasia 156550
Avascular necrosis of the femoral head 608805
Vitreoretinopathy with phalangeal epiphyseal dysplasia
Epiphyseal dysplasia, multiple, with myopia and deafness 132450
Spondyloepiphyseal dysplasia, Stanescu type 616583
Platyspondylic skeletal dysplasia, Torrance type 151210
Spondyloperipheral dysplasia 271700
GENE ONTOLOGY
Ontology GO Term
Biological Process notochord development (more)
Cellular Component collagen trimer (more)
Molecular Function extracellular matrix structural constituent (more)
GO Terms (all 4)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR000885 (1)
  • InterPro:IPR001007 (1)
  • InterPro:IPR008160 (1)
  • InterPro:IPR014716 (1)
  • InterPro:IPR016133 (1)
  • PROSITE:PS01208 (1)
  • PROSITE:PS50184 (1)
  • PROSITE:PS51461 (1)
  • Pfam:PF00093 (1)
  • Pfam:PF01391 (1)
  • Pfam:PF01410 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA col2a1a-001 (1) 5937
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM col2a1a
    Tg(-1.7col2a1a:EGFP-CAAX), Tg(col2a1a:bmpr1aa), Tg(col2a1a:EGFP), Tg(col2a1a:GAL4FF), Tg(col2a1a:GFP) (all 10) expand
    MARKER RELATIONSHIPS
    col2a1aContained in: [BAC] CH211-216K22 (1) (order this)
    col2a1aEncodes: [EST] fb38c06 (1), fc10c01 (1)
    [cDNA] MGC:174994 (1), MGC:195369 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131292 (1) 4862bp
    Genomic GenBank:BX927144 (1) 168503bp
    Select Tool
    Polypeptide UniProtKB:B3DKQ3 (1) 1491aa
    Sequence Clusters UniGene:75057 (1)
    Sequence Information (all 33)
    OTHER col2a1a GENE PAGES
  • Alliance (1)
  • Gene:562496 (1)
  • VEGA:OTTDARG00000020587 (1)
  • Ensembl(GRCz10):ENSDARG00000069093 (1)
  • ORTHOLOGY for col2a1a (Chr: 8)
    CITATIONS (198)