ZFIN ID: ZDB-GENE-980526-170
Gene Name: cadherin 11, type 2, OB-cadherin (osteoblast)
Gene Symbol: cdh11    Nomenclature History

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Previous Names: cdhvn, ventral neural cadherin, vnc

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have cadherin binding activity and calcium ion binding activity. Involved in otolith development; retina development in camera-type eye; and retinal ganglion cell axon guidance. Predicted to localize to adherens junction and catenin complex. Is expressed in cleithrum; nervous system; optic vesicle; and pectoral fin bud. Human ortholog(s) of this gene implicated in Elsahy-Waters syndrome. Orthologous to human CDH11 (cadherin 11).
Genome Resources: Alliance (1),  Gene:30461 (1),  Ensembl(GRCz11):ENSDARG00000021442 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
el520 Small Deletion Unknown Unknown TALEN
mn0010Gt Transgenic Insertion Unknown Unknown DNA
sa14413 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa27024 Point Mutation Unknown Missense ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa31589 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-cdh11 N/A 2
    MO2-cdh11 N/A 2
    MO3-cdh11 N/A 2
    TALEN1-cdh11 1
    DISEASE ASSOCIATED WITH cdh11 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Elsahy-Waters syndrome Alliance Elsahy-Waters syndrome 211380
    DISEASE ASSOCIATED WITH cdh11 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process otolith development (more)
    Cellular Component integral component of membrane (more)
    Molecular Function calcium ion binding (more)
    GO Terms (all 18)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA cdh11-201 (1)    Ensembl 4068
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES
    Name Type Isotype Host Organism Assay Source Publications
    Ab1-cdh11 polyclonal Rabbit IHC, WB 2
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM cdh11 No data available
    MARKER RELATIONSHIPS
    cdh11 Contained in: [BAC] CH211-155A19 (1)
    cdh11 Encodes: [EST] wz12628 (1)
    [cDNA] MGC:194061 (1), MGC:194085 (1), MGC:194941 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_131214 (1) 2741 nt
    Genomic GenBank:CT025913 (1) 192923 nt
    Select Tool
    Polypeptide UniProtKB:B3DGG4 (1) 800 aa
    Sequence Information (all 28)
    ORTHOLOGY for cdh11 ( Chr: 7 )
    CITATIONS (39)