ZFIN ID: ZDB-GENE-141216-16
Gene Name: gamma-aminobutyric acid type A receptor subunit alpha2a
Gene Symbol: gabra2a    Nomenclature History

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Previous Name: si:dkey-52k1.6

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 13 Mapping Details/Browsers
Description: Predicted to contribute to GABA-A receptor activity; benzodiazepine receptor activity; and chloride channel activity. Predicted to be involved in several processes, including GABAergic synaptic transmission; chloride transmembrane transport; and gamma-aminobutyric acid signaling pathway. Predicted to localize to several cellular components, including GABA-A receptor complex; dendrite membrane; and postsynapse. Is expressed in caudal fin; nervous system; neural tube; and tail bud. Human ortholog(s) of this gene implicated in alcohol use disorder; autistic disorder; and early infantile epileptic encephalopathy. Orthologous to human GABRA2 (gamma-aminobutyric acid type A receptor subunit alpha2).
Genome Resources: Alliance (1),  Ensembl(GRCz11):ENSDARG00000091459 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-gabra2a N/A 1
DISEASE ASSOCIATED WITH gabra2a HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
alcohol dependence Alliance {Alcohol dependence, susceptibility to} 103780
Epileptic encephalopathy, early infantile, 78 618557
DISEASE ASSOCIATED WITH gabra2a VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process chloride transport (more)
Cellular Component integral component of membrane (more)
Molecular Function extracellular ligand-gated ion channel activity (more)
GO Terms (all 30)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA gabra2a-202 (1)    Ensembl 1530
Browsers: NCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM gabra2a No data available
MARKER RELATIONSHIPS
gabra2a Contained in: [BAC] DKEY-52K1 (1) (order this)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
Genomic GenBank:CR792443 (1) 217981 nt Blast at MegaBLAST
Polypeptide UniProtKB:E7F635 (1) 451 aa
Sequence Information (all 3)
ORTHOLOGY for gabra2a ( Chr: 13 )
CITATIONS (14)